Article

[Mitochondrial DNA coding region 3954-4506 polymorphism in Korean Chinese population].

Department of Forensic Medicine, School of Medicine, Yanbian University, Yanji, Jilin, 133000 PR China.
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 03/2009; 26(1):106-8. DOI:10.3760/cma.j.issn.1003-9406.2009.01.025 pp.106-8
Source: PubMed

ABSTRACT To investigate the sequence polymorphism of mtDNA coding region encompassing nt3954-4506 in the Korean Chinese population of Yanbian area.
Polymerase chain reaction (PCR) and direct sequencing method were used to detect the haplotype distribution of mtDNA coding region in 198 Korean Chinese individuals.
Twenty-one haplotypes were observed in the 198 unrelated individuals. The genetic diversity was 0.5906 and the random match probability was 0.4124. Compared with the Andersonos sequence, 19 nucleotide variants were found, of which 14 were previously registered in MITOMAP, and 5 were novel.
The obtained data suggest that these sequence polymorphisms are valuable genetic markers for personal identification when combined with mtDAN control region investigation, thus could be used as basic data for the forensic application in Korean Chinese population.

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Keywords

198 Korean Chinese individuals
 
198 unrelated individuals
 
basic data
 
direct sequencing method
 
forensic application
 
genetic diversity
 
haplotype distribution
 
haplotypes
 
MITOMAP
 
mtDAN control region investigation
 
mtDNA coding region
 
mtDNA coding region encompassing nt3954-4506
 
personal identification
 
random match probability
 
Yanbian area
 

YongJi Zhang