Animal-associated bacteria, Erysipelotrix rhusiopathiae, as the cause of infection in a total hip arthroplasty.
ABSTRACT Invasive infection with animal-associated bacteria, Erysipelotrix rhusiopathiae, is unusual and has, to our knowledge, never been described as the cause of infected total hip arthroplasty. We describe how an infected total hip arthroplasty caused by these bacteria is eradicated using standard surgical and antibiotic treatment. Before 2-stage revision surgery, the patient had persistent groin pain, elevated C-reactive protein, radiographic periprosthetic osteolysis, excessive intra-articular fluid, and periprosthetic activity accumulation on the white cell scan. The patient was treated with benzylpenicillin after confirmed sensitivity of E rhusiopathiae diagnosed by culture of five tissue samples and polymerase chain reaction of the prosthetic sonicate sample. Sixteen weeks after the last stage of revision surgery, there were no signs of reoccurring infection.
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ABSTRACT: Objective: To evaluate antidiabetic and antioxidant role of methanol extract of Streblus asper root bark in Wistar rats. Methods: Diabetes was induced in rats by single intraperitoneal injection of streptozotocin (STZ, 65 mg/kg body weight). Three days after STZ induction, the diabetic rats were treated with S. asper orally at the dose of 200 and 400 mg/kg body weight daily for 15 days. Glibenclamide (0.25 mg/kg, orally) was used as reference drug. The fasting blood glucose levels were measured on every fifth day during the 15-days treatment. Serum biochemical parameters such as serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), serum alkaline phosphatase (SALP), total cholesterol total protein and serum triglycerides were estimated. Antioxidant properties were assessed by estimating liver and kidney thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH) and catalase (CAT). Results: S. asper in STZ-induced diabetic rats, at the doses of 200 and 400 mg/kg b.w. produced reduction in blood glucose levels when compared with the STZ- control group. Serum biochemical parameters antioxidant levels were significantly restored toward normal levels in S. asper treated rats as compared with STZ control. Conclusion: The present study infers that the methanol extract of S. asper root bark demonstrated remarkable antidiabetic activity in STZ-induced diabetic rats. The potential antidiabetic action is plausibly due to its underlying antioxidant role.Asian Pacific Journal of Tropical Disease. 04/2012; 2(2):139-143.
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ABSTRACT: Erysipelothrix rhusiopathiae is an established animal pathogen while the zoonotic infections in humans are rarely reported. Infections occur after exposure to animals or animal products that are mostly occupational in adults. Here we report in a child for the first time septic arthritis and osteomyelitis without an identifiable risk factor. A 5-year-old male child was admitted with pain in the left hip joint and inability to bear weight on the limb. Clinical examination followed by radiological and magnetic resonance imaging was suggestive of septic arthritis. Erysipelothrix rhusiopathiae grew from peroperative joint specimen. The infection was resolved following arthrotomy, joint lavage and antibiotic therapy.Asian Pacific Journal of Tropical Biomedicine 06/2012; 2(6):503-4.
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ABSTRACT: This report describes two cases of cutaneous cellulitis in workers at the same poultry farm in the rural area of Tandil, Argentina. In both patients E. rhusiopathiae was identified from culture samples obtained through biopsy. Investigation of the reservoir showed that in all samples of fowl waste and in 2 samples of feed E. rhusiopathiae was isolated with identical biochemical and antibiotic resistance profiles to those of the isolated strains in the case reports. Even though molecular analyses are required to establish an epidemiologic relation between the strains found in the patients and those in the farm, it can be inferred that the source of the human infection was the extensive poultry farm.Acta Bioquímica Clínica Latinoamericana. 01/2011; 45:119-124.