Article

Calcitonin gene-related peptide levels in saliva of patients with burning mouth syndrome.

Institute of Neurology, Clinical Center of Serbia, Belgrade, Serbia.
Journal of Oral Pathology and Medicine (impact factor: 1.63). 02/2009; 38(1):29-33. DOI:10.1111/j.1600-0714.2008.00721.x
Source: PubMed

ABSTRACT Burning mouth syndrome (BMS) is an intraoral burning sensation for which no medical or dental cause can be found. Recent studies suggest that primary neuropathic dysfunction might be involved in the pathogenesis of BMS. Calcitonin gene-related peptide (CGRP) plays an important role in the development of pain and serves as a biological marker of trigeminovascular activation. The aim of this study was to determine the levels of CGRP in the saliva of BMS patients and estimate the trigeminovascular activation in BMS. CGRP levels were measured, by RIA method in 78 BMS patients and 16 healthy subjects. The levels of CGRP were non-significantly decreased in BMS patients in comparison to healthy subjects. These results suggest that trigeminal nerve degeneration may be the underlying cause of BMS.

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    Article: Salivary and serum levels of substance P, neurokinin A and calcitonin gene related peptide in burning mouth syndrome.
    Vanja-Vucicevic Boras, Neil-William Savage, Vlaho Brailo, Josip Lukac, Maja Lukac, Iva Z Alajbeg
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    ABSTRACT: Burning mouth syndrome (BMS) is an enigmatic condition with the aetiopathogenesis remaining largely obscure. However, a neuropathic basis for BMS continues to be an area of active clinical and research interest. It is becoming increasingly evident that certain oral disorders may be modulated by imbalances in certain neuropeptides such as substance P (SP), neurokinin A (NKA) and calcitonin gene-related peptide (CGRP) therefore we measured SP, NKA and CGRP in the saliva and sera of BMS patients as well as controls. Salivary and serum SP, NKA and CGRP were determined in the 26 female patients with burning mouth syndrome (age range 51-78, mean 65.69 yrs), and in the 22 female controls (age range 24-82, mean 49.72 yrs). Serum and salivary SP, NKA, CGRP levels were determined by commercial competitive enzyme immunoassay kits. Statistical analysis was performed by use of descriptive statistics and analysis of variance. No significant differences in salivary SP, NKA and CGRP as well as serum SP and CGRP between BMS patients and controls could be found. However, significantly decreased serum neurokinin A (p<0.05) in BMS patients may reflect an inefficient dopaminergic system.
    Medicina oral, patologia oral y cirugia bucal 05/2010; 15(3):e427-31.
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Keywords

16 healthy subjects
 
78 BMS patients
 
biological marker
 
BMS patients
 
Burning mouth syndrome
 
Calcitonin gene-related peptide
 
CGRP
 
CGRP levels
 
dental cause
 
medical
 
primary neuropathic dysfunction
 
Recent studies
 
RIA method
 
saliva
 
trigeminal nerve degeneration
 
trigeminovascular activation
 
underlying cause