Preparation of Uniform Microspheres Using a Simple Fluidic Device and Their Crystallization into Close-Packed Lattices

Department of Biomedical Engineering, Washington University, St. Louis, Missouri 63130, USA.
Small (Impact Factor: 8.37). 02/2009; 5(4):454-9. DOI: 10.1002/smll.200801498
Source: PubMed


The preparation of uniform raspberry-like microspheres using a simple fluidics device and their crystallization into close-packed lattices was investigated. The spheres was developed by stable Oil-in-Water (O/W) or Water-in-Oil (W/O) emulsions and scanning Electron Microscopy (SEM) of close packed lattices was done. Various types of microfluidic devices have been developed to generate microparticles with diverse morphologies such as spheres, rods, disks and ellipsoids. The device provided precise control over the formation of emulsion droplets, leading to the production of uniform microspheres in size ranging from 30 to 250 μm. The technique provided a powerful strategy for the scalable and continuous production of microspheres from both organic and inorganic materials actively sought for encapsulation of drugs, dyes, and tissue engineering.

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