Article

Synthesis and in vitro antitubercular activity of a series of quinoline derivatives.

FioCruz-Fundação Oswaldo Cruz, Instituto de Tecnologia em Fármacos-Far Manguinhos, Manguinhos, Rio de Janeiro, Brazil.
Bioorganic & medicinal chemistry (impact factor: 2.82). 02/2009; 17(4):1474-80. DOI:10.1016/j.bmc.2009.01.013 pp.1474-80
Source: PubMed

ABSTRACT A series of 33 quinoline derivatives have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H(37)Rv using the Alamar Blue susceptibility test and the activity expressed as the minimum inhibitory concentration (MIC) in microg/mL. Compounds 5e and 5f exhibited a significant activity at 6.25 and 3.12 microg/mL, respectively, when compared with first line drugs such as ethambutol and could be a good starting point to develop new lead compounds in the fight against multi-drug resistant tuberculosis.

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Keywords

33 quinoline derivatives
 
5f exhibited
 
Alamar Blue susceptibility test
 
first line drugs
 
minimum inhibitory concentration
 
multi-drug resistant tuberculosis
 
Mycobacterium tuberculosis H(37)Rv
 
new lead compounds
 
vitro antibacterial activity