Positive Screening on the Modified Checklist for Autism in Toddlers (M-CHAT) in Extremely Low Gestational Age Newborns

Division of Pediatric Neurology, Department of Pediatrics, Boston Medical Center, Boston University, Boston, MA 02118, USA.
The Journal of pediatrics (Impact Factor: 3.74). 04/2009; 154(4):535-540.e1. DOI: 10.1016/j.jpeds.2008.10.011
Source: PubMed

ABSTRACT To test the hypothesis that children born preterm are more likely to screen positive on the M-CHAT for an autism spectrum disorder.
We compared the M-CHAT positive rate of those with cerebral palsy, cognitive impairment, and vision and hearing impairments to those without such deficits.
Relative to children who could walk, the odds for screening positive on the M-CHAT were increased 23-fold for those unable to sit or stand independently and more than 7-fold for those requiring assistance to walk. Compared with children without a diagnosis of cerebral palsy, those with quadriparesis were 13 times more likely to screen positive, and those with hemiparesis were 4 times more likely to screen positive. Children with major vision or hearing impairments were 8 times more likely to screen positive than those without such impairments. Relative to those with a Mental Development Index (MDI) of >70, the odds for screening positive were increased 13-fold for those with an MDI of <55 and more than 4-fold for those with an MDI of 55 to 69.
Major motor, cognitive, visual, and hearing impairments appear to account for more than half of the positive M-CHAT screens in extremely low gestational age newborns. Even after those with such impairments were eliminated, 10% of children--nearly double the expected rate--screened positive.

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Available from: Helen Tager-Flusberg, Jul 28, 2015
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    • "Several prospective studies of ASD in preterm population (based on parental questionnaire-based data) have demonstrated a comparatively elevated risk for ASD in preterm children , although the incidence of ASD varied widely between studies (19.4–41%) (Sargent, 1993; Zenclussen et al., 2007; Limperopoulos et al., 2008; Hack et al., 2009; Kuban et al., 2009; Moore et al., 2012). The populations examined all consisted of extremely preterm children (<28 weeks) or of very low birth weight (<1500 g), and the children were assessed for ASD at less than three years of age. "
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    • "Further research of the psychometric properties of the M-CHAT has been conducted (L. C. Eaves, Wingert, & Ho, 2006; Kleinman, et al., 2008; Kuban, et al., 2009; Pandey, et al., 2008; Robins, 2008; Snow & Lecavalier, 2008). "
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