Article

Proteomics of skeletal muscle aging.

Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Proteomics (impact factor: 4.43). 02/2009; 9(4):989-1003. DOI:10.1002/pmic.200800365
Source: PubMed

ABSTRACT Extended human longevity has resulted in increasing numbers of elderly persons in the general population. However, old age is also associated with a variety of serious physical disorders. Frailty among sedentary elderly patients is related to the impaired structure and function of contractile fibers. Biochemical research into cellular mechanisms that underlie sarcopenia promises to acquire the scientific basis of evidence to aid the development of new diagnostic and therapeutic strategies. The recent application of MS-based proteomic methodology has identified a large cohort of disease-specific markers of sarcopenia. This review critically examines the biomedical implications of the results obtained from the proteomic screening of both aged human muscle and established animal models of sarcopenia. Substantial alterations in proteins involved in key metabolic pathways, regulatory and contractile elements of the actomyosin apparatus, myofibrillar remodeling and the cellular stress response are discussed. A multi-factorial etiology appears to be the basis for a slower-twitching aged fiber population, which exhibits a shift to more aerobic-oxidative metabolism. It is hoped that the detailed biomedical characterization of the newly identified biomarkers of sarcopenia will translate into better treatment options for reversing age-dependent muscle degeneration, which could improve the standard of living for a large portion of society.

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Keywords

age-dependent muscle degeneration
 
biomedical implications
 
cellular mechanisms
 
cellular stress response
 
contractile fibers
 
detailed biomedical characterization
 
disease-specific markers
 
elderly persons
 
Extended human longevity
 
fiber population
 
general population
 
identified biomarkers
 
impaired structure
 
key metabolic pathways
 
MS-based proteomic methodology
 
proteomic screening
 
scientific basis
 
sedentary elderly patients
 
treatment options
 
underlie sarcopenia promises