Article

Fast Disinfecting Antimicrobial Surfaces

Department of Polymer Science & Engineering, University of Massachusetts, Amherst, Massachusetts 01003, USA.
Langmuir (Impact Factor: 4.38). 02/2009; 25(2):1060-7. DOI: 10.1021/la802953v
Source: PubMed

ABSTRACT Silicon wafers and glass surfaces were functionalized with facially amphiphilic antimicrobial copolymers using the "grafting from" technique. Surface-initiated atom transfer radical polymerization (ATRP) was used to grow poly(butylmethacrylate)-co-poly(Boc-aminoethyl methacrylate) from the surfaces. Upon Boc-deprotection, these surfaces became highly antimicrobial and killed S. aureus and E. coli 100% in less than 5 min. The molecular weight and grafting density of the polymer were controlled by varying the polymerization time and initiator surface density. Antimicrobial studies showed that the killing efficiency of these surfaces was independent of polymer layer thickness or grafting density within the range of surfaces studied.

Download full-text

Full-text

Available from: Ahmad E Madkour, Nov 15, 2014
1 Follower
 · 
168 Views
  • Source
    • ") from the bacterial phospholipid membrane upon interactions with AMPs, leading to electrostatic imbalance on the membrane surface (Kugler et al., 2005; Madkour et al., 2009). This charge imbalance will alter the Donnan potential across the cytoplasmic membrane, which will ultimately trigger fatal cellular events such as the activation of autolytic enzymes or the disruption of electrostatic balance of internal layers (Hilpert et al., 2009). "
    [Show abstract] [Hide abstract]
    ABSTRACT: Antimicrobial peptides (AMPs) are next generation antibiotics which will make excellent coating agents for a myriad of devices because they are far less susceptible to the development of pathogen resistance compared to conventional antibiotics, exhibit rapid and broad-spectrum killing profiles, and are effective at low concentrations. These advantages, however, are compromised upon AMP tethering to solid supports. The effects of peptide-tethering strategies in governing AMP orientation, surface density, flexibility, and activity are reviewed. Understanding AMP structure-function relationship in the tethered conformation will enable rational improvements of immobilisation parameters. Foreseeable challenges in the development of AMP-coated devices such as microbial accumulation on implant surface and the lack of direct biomolecular structure and orientation data of peptides on surfaces are also discussed, and solutions to address these roadblocks are also proposed.
    Biotechnology advances 01/2011; 29(1):67-74. DOI:10.1016/j.biotechadv.2010.08.012 · 8.91 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: A novel encapsulated flame retardant containing phosphorus-nitrogen (MSMM-Al-P) was prepared by encapsulating with polyamide 66 (PA66-MSMM-Al-P) for the flame retardation of polyamide 6 (PA6). The structure and thermal properties of PA66-MSMM-Al-P were characterized by Fourier-transform infrared spectroscopy, X-ray photoelectron spectroscopy and thermogravimetric analysis. The flammability of PA6 containing flame retardants (MSMMAl-P and PA66-MSMM-Al-P) was investigated by the limiting oxygen index test, vertical burning test and cone calorimeter. The flame retardancy and cone calorimetric analyses suggested a synergistic effect between PA66 and MSMM-Al-P in the flame-retardant PA6. Thermal stability of the flame-retardant PA6 was also investigated.
    Chinese Journal of Polymer Science 03/2012; 30(2). DOI:10.1007/s10118-012-1126-2 · 1.42 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Not Available
    1974 Ultrasonics Symposium; 02/1974
Show more