Article
A new weighting function to achieve high temporal resolution in circular cone-beam CT with shifted detectors.
Institute of Medical Physics, University of Erlangen-Nürnberg, Erlangen, Germany.
Medical Physics (impact factor:
2.83).
01/2009;
35(12):5898-909.
pp.5898-909
Source: PubMed
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Citations (0)
- Cited In (3)
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Conference Proceeding: Low-dose phase-correlated cone-beam micro-CT of small animals
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ABSTRACT: Double-gated in-vivo small animal cone-beam micro-CT scans provide five-dimensional information about the object: the three volume dimensions plus the temporal dimensions of the respiratory motion and the heart motion, respectively. Double gating is typically performed to separate respiratory from cardiac motion when imaging the animal's lung or heart.Nuclear Science Symposium Conference Record (NSS/MIC), 2010 IEEE; 12/2010 -
Article: Low-dose cardio-respiratory phase-correlated cone-beam micro-CT of small animals.
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ABSTRACT: Micro-CT imaging of animal hearts typically requires a double gating procedure because scans during a breath-hold are not possible due to the long scan times and the high respiratory rates, Simultaneous respiratory and cardiac gating can either be done prospectively or retrospectively. True five-dimensional information can be either retrieved with retrospective gating or with prospective gating if several prospective gates are acquired. In any case, the amount of information available to reconstruct one volume for a given respiratory and cardiac phase is orders of magnitud lower than the total amount of information acquired. For example, the reconstruction of a volume from a 10% wide respiratory and a 20% wide cardiac window uses only 2% of the data acquired. Achieving a similar image quality as a nongated scan would therefore require to increase the amount of data and thereby the dose to the animal by up to a factor of 50. To achieve the goal of low-dose phase-correlated (LDPC) imaging, the authors propose to use a highly efficient combination of slightly modified existing algorithms. In particular, the authors developed a variant of the McKinnon-Bates image reconstruction algorithm and combined it with bilateral filtering in up to five dimensions to significantly reduce image noise without impairing spatial or temporal resolution. The preliminary results indicate that the proposed LDPC reconstruction method typically reduces image noise by a factor of up to 6 (e.g., from 170 to 30 HU), while the dose values lie in a range from 60 to 500 mGy. Compared to other publications that apply 250-1800 mGy for the same task [C. T. Badea et al., "4D micro-CT of the mouse heart," Mol. Imaging 4(2), 110-116 (2005); M. Drangova et al., "Fast retrospectively gated quantitative four-dimensional (4D) cardiac micro computed tomography imaging of free-breathing mice," Invest. Radiol. 42(2), 85-94 (2007); S. H. Bartling et al., "Retrospective motion gating in small animal CT of mice and rats," Invest. Radiol. 42(10), 704-714 (2007)], the authors' LDPC approach therefore achieves a more than tenfold dose usage improvement. The LDPC reconstruction method improves phase-correlated imaging from highly undersampled data. Artifacts caused by sparse angular sampling are removed and the image noise is decreased, while spatial and temporal resolution are preserved. Thus, the administered dose per animal can be decreased allowing for long-term studies with reduced metabolic inference.Medical Physics 03/2011; 38(3):1416-24. · 2.83 Impact Factor -
Conference Proceeding: Simple ROI Cone--Beam Computed Tomography
Nuclear Science Symposium Conference Record (NSS/MIC); 12/2010
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Keywords
360 degrees angular coverage
angular direction
backprojection
complete data
computed tomography
detector partial scan algorithm
dual source micro-CT scanner
dynamic CT data
full scan
inner FOM
lateral dimensions
new weighting function
outer FOM
overscan data
partial scan reconstruction
partial scan window
raw data
rotating gantry
transaxial FOM diameter
Well-known weighting functions