Relationship between serum adipocytokine levels and metabolic syndrome in menopausal women.
ABSTRACT Adipocytokines are bioactive substances derived from adipose tissues, especially visceral fat, and play a crucial role in the development of metabolic syndrome. The aims of this study were to estimate serum levels of adipocytokines (adiponectin, resistin and TNF-alpha) and to examine the associations between adipocytokine levels and metabolic syndrome in menopausal women.
We recruited 28 postmenopausal women with features of metabolic syndrome. For the purpose of comparing adipocytokine levels, 30 postmenopausal women without metabolic syndrome were recruited by matching age and body mass index (BMI). Serum levels of adipocytokines (adiponectin, resistin, TNF-alpha) were then determined, and any potential correlations between adipocytokine levels and metabolic syndrome were investigated.
There were no significant differences in adiponectin or resistin levels in women with metabolic syndrome when compared with the control group. Conversely, TNF-alpha levels were significantly higher in women with metabolic syndrome. Furthermore, multivariate logistic regression analysis indicated that TNF-alpha was significantly associated with metabolic syndrome.
Our results suggest that, among the adipocytokines (adiponectin, resistin and TNF-alpha), serum TNF-alpha levels may serve as a useful biomarker for diagnosing metabolic syndrome in menopausal women.
Article: Postmenopausal hypertension.[Show abstract] [Hide abstract]
ABSTRACT: Cardiovascular disease is the leading cause of morbidity and mortality in postmenopausal women. Hypertension is a major risk factor for cardiovascular disease. The mechanisms responsible for postmenopausal hypertension have not been completely elucidated. However, various mechanisms have been implicated to play a role. For example, there is evidence that changes in estrogen/androgen ratios favoring increases in androgens, activation of the renin-angiotensin and endothelin systems, activation of the sympathetic nervous system, metabolic syndrome and obesity, inflammation, increased vasoconstrictor eicosanoids, and anxiety and depression may be important in the pathogenesis of postmenopausal hypertension. There is also evidence that hypertension is less well controlled in aging women than in aging men, but the reasons for this gender difference is not clear. Postmenopausal hypertension is likely multifactorial. Future studies will be necessary to determine the contribution of these systems listed above in mediating postmenopausal hypertension and to design treatment strategies that encompass these mechanisms to improve the quality of life of postmenopausal women as they age.American Journal of Hypertension 07/2011; 24(7):740-9. · 3.67 Impact Factor
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ABSTRACT: The purpose of the present study was to test the anti-inflammatory and blood glucose (BG)-regulating capacity of strawberries in a mouse model of diet-induced obesity. A total of thirty-six male C57BL/6J mice were randomly divided into four groups (nine mice per group). Mice were fed a low-fat diet (LF, 13 % fat), the LF supplemented with 2·6 % freeze-dried strawberry powder (LFSB), a high-fat diet (HF, 44 % fat) or the HF supplemented with 2·6 % strawberry powder (HFSB). Blood samples were collected to measure BG, inflammation and systemic markers for endocrine function of pancreas and adipose tissue. Splenocytes were harvested at the end of the study and activated with either anti-cluster of differentiation (CD) 3/anti-CD28 antibodies or lipopolysaccharide to test immune responsiveness. The HF increased non-fasted BG, insulin, soluble intracellular adhesion molecule-1, E-selectin, leptin, resistin and plasminogen activator protein-1 (P < 0·05). High dietary fat decreased IL-4 production from activated splenocytes (P < 0·05). BG concentrations were lower in the mice supplemented with SB (10·64 mmol/l) compared to the non-supplemented mice (11·37 mmol/l; P = 0·0022). BG values were approximately 6·5 % lower in the supplemented mice. Additionally, SB lowered plasma C-reactive protein in the LFSB group compared to the other three groups (P < 0·05). The dietary intake of SB approximated one human serving of strawberries. These results, although modest, support a promising role for dietary strawberries in reducing the risks associated with obesity and diabetes, and regulating the levels of inflammatory markers in non-obese individuals.The British journal of nutrition 02/2012; · 3.45 Impact Factor