Functionalization of Mesoporous Silica Nanoparticles for Targeting, Biocompatibility, Combined Cancer Therapies and Theragnosis

Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan.
Journal of Nanoscience and Nanotechnology (Impact Factor: 1.34). 04/2013; 13(4):2399-430. DOI: 10.1166/jnn.2013.7363
Source: PubMed

ABSTRACT The advent of Nanotechnology has paved a way for improved disease treatment strategies, the most noteworthy being the mesoporous silica nanoparticles (MSNs) which have gained much recent attention in the field of cancer therapy and its diagnosis. The flaws of the current-day strategies can be overcome by this superior technology through its targeting ability in delivering drugs and image able agents specifically to the tumor sites. MSNs have unique biocompatibility features, its high surface area which contributes in large amount of drug loading and its facility to monitor size and shape of the nanoparticles are few of the positives which makes this technology an enormous asset for the field of Nanotechnology. This review paper is structured in such a way wherein we initially have discussed about the synthesis methods and various functionalization approaches for MSN followed by the different methods used for targeting cancer cells and the latest advances in controlled drug release. Some of the highlights of this review are the biocompatibility of MSNs, in vivo results of MSNs on cancer therapy. This review paper also shortly discuss about combined cancer therapies to overcome the challenges in current-day cancer treatment. Finally, we converge briefly on the recent advancements in the use of hybrid MSNs for obtaining multiple functions.

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