Efficacy of αs1-casein hydrolysate on stress-related symptoms in women

Department of Integrative Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
European Journal of Clinical Nutrition (Impact Factor: 2.95). 01/2007; 61(4):536-541. DOI: 10.1038/sj.ejcn.1602553
Source: PubMed

ABSTRACT Objective:To examine the effects of αs1-casein hydrolysate on females with stress-related symptoms.Design:Double-blind, randomized, crossover, placebo-controlled trial.Setting:The αs1-casein hydrolysate was manufactured by INGREDIA (Arras, France) and the placebo was manufactured by DIETAROMA (Bourg, France). Study was designed and performed at PROCLAIM (Rennes, France), and the statistical analyses were performed by D Desor (Nancy, France).Subjects:A total of 63 female volunteers suffering from at least one disorder that may be related to stress such as anxiety, sleep problems and general fatigue.Interventions:A total of 63 volunteers participated in a double-blind, randomized, crossover, placebo-controlled study. Subjects were randomly allocated to receive either tablets containing αs1-casein hydrolysate or placebo at the dose of 150 mg/day for 30 days. After a 3 weeks washout period, they were crossed over for a new 30-day period of tablets intake. The outcome measure was a questionnaire including 44 items of symptoms that may be related stress in which the severity of each sign was evaluated using a 10-degree scale. These measures were studied repeatedly at the day of 0, 15 and 30 after the start of each interventional period.Results:The 30-day treatment by αs1-casein hydrolysate in females with stress-related symptoms reduced their symptoms, particularly in digestion (P

  • [Show abstract] [Hide abstract]
    ABSTRACT: Alpha-casozepine, a decapeptide derived from bovine milk α-S 1 casein, has well-documented anxiolytic properties in several species. To evaluate potential benefit of alpha-casozepine to horses’ compliance and comfort with routine management and healthcare procedures, we blindly compared behavior of alpha-casozepine- and control-supplemented horses with known specific aversions to specific healthcare procedures. Twenty-six light horse mares were first screened for aversions based on compliance and apparent comfort during a standard battery of 12 healthcare examinations and treatment procedures. Based on quantitative behavioral analysis of videorecorded sessions, baseline compliance/comfort with each procedure was scored from 0 (unable to progress) to 10 (excellent compliance and relaxed comfort. Based on those results, 10 of the 26 were selected as five pairs that were matched for breed and the same two specific aversions. One of each pair was randomly assigned to alpha-casozepine supplementaiton (2000 mg PO daily) and the other to control supplement for five days. On Day 5 of supplementation, the standard battery of 12 procedures was repeated. For the five alpha-casozepine-supplemented subjects, compliance/comfort scores improved for seven of their ten aversions, compared to one of ten for the five matched controls (P < 0.01, Fisher’s Exact). Average scores increased 1.5 (SE = 0.87) points for alpha-casozepine aversions, compared to an average decrease of 0.92 (SE = 0.61) points for matched control aversions (P < 0.05, Wilcoxin signed ranks. These results indicate a modest benefit of alpha-casozepine supplementation to horses for improvement of compliance and apparent comfort with mildly aversive routine healthcare procedures.
    Journal of Equine Veterinary Science 08/2014; · 0.89 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: This study describes the effect of bovine alpha-S1 casein tryptic hydrolysate (CTH) in a representative sample of day-time workers from the general population of Japan with the occurrence of insomnia during the preceding six months. To investigate this issue, 32 subjects, aged between 25 and 40 years, were examined for the sub- jective sleep quality using the Japanese Pittsburg Sleep Quality Index (PSQI-J). CTH significantly improves the PSQI total score of the treated subjects. It particularly improves the sleep quality after two weeks of treatment, decreases the sleep latency and the daytime dysfunction after four weeks of treatment. Given the antistress properties of CTH, it seems possible to relate the detected improvement of sleep aspects to a reduc- tion of stress following its' chronic administration. In conclusion, being given its beneficial effects and its absence of negative side effects, it would be advantageous to use the CTH to improve chronic insomnia in the Japanese general population. However, further studies will be necessary in order to clarify the essential aspect of CTH properties in the sleep problems.
    The Open Sleep Journal 05/2009; 2(1):26-32.
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: During food digestion, proteins are hydrolysed into a large variety of peptides. Some of these peptides are structurally similar to sequences acting in the organism as endogenous signals, or hormones. Therefore, homologous food peptides can interact with the same receptors or enzymes in the organism, and in this form, exert an agonistic or antagonistic activity. The evidence of the potential of these dietary peptides to modulate numerous physiological conditions has been mainly achieved using in vitro assays; however, it is accepted that health evidence has to be based on in vivo trials (animals or humans) since the activity of these molecules depends on the ability of these peptides to reach the target tissue in an active form, which in turn depends on their structure. This article reviews the literature on the physiological effects of milk-derived bioactive peptides with special emphasis in the evidence achieved in animal and human trials.
    International Dairy Journal 10/2014; 38(2):82–100. · 2.30 Impact Factor

Full-text (2 Sources)

Available from
Jul 3, 2014