Castanotto D, Rossi JJThe promises and pitfalls of RNA-interference-based therapeutics. Nature 457:426-433

Department of Molecular Biology and City of Hope Graduate School of Biological Sciences, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA.
Nature (Impact Factor: 42.35). 02/2009; 457(7228):426-33. DOI: 10.1038/nature07758
Source: PubMed

ABSTRACT The discovery that gene expression can be controlled by the Watson-Crick base-pairing of small RNAs with messenger RNAs containing complementary sequence - a process known as RNA interference - has markedly advanced our understanding of eukaryotic gene regulation and function. The ability of short RNA sequences to modulate gene expression has provided a powerful tool with which to study gene function and is set to revolutionize the treatment of disease. Remarkably, despite being just one decade from its discovery, the phenomenon is already being used therapeutically in human clinical trials, and biotechnology companies that focus on RNA-interference-based therapeutics are already publicly traded.

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Available from: John J Rossi, Jun 22, 2015
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    • "The importance and applications of transition metal–ligand complexes are widespread from synthetic chemistry to material science and biochemistry. These metals have been used for drug design and delivery [12] [13] [14] [15] [16] [17], catalysis [18] [19] [20] [21], solar cell applications [22] [23] [24], and biological imaging [25] [26]. In biological systems , transition metals are involved with very specific structural and cellular functions. "
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