Article

Green tea inhibits Helicobacter growth in vivo and in vitro.

Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA.
International journal of antimicrobial agents (impact factor: 3.03). 02/2009; 33(5):473-8. DOI:10.1016/j.ijantimicag.2008.10.032 pp.473-8
Source: PubMed

ABSTRACT Helicobacter infection, one of the most common bacterial infections in man worldwide, is a type 1 carcinogen and the most important risk factor for gastric cancer. Helicobacter pylori bacterial factors, components of the host genetics and immune response, dietary cofactors and decreased acid secretion resulting in bacterial overgrowth are all considered important factors for induction of gastric cancer. Components found in green tea have been shown to inhibit bacterial growth, including the growth of Helicobacter spp. In this study, we assessed the bactericidal and/or bacteriostatic effect of green tea against Helicobacter felis and H. pylori in vitro and evaluated the effects of green tea on the development of Helicobacter-induced gastritis in an animal model. Our data clearly demonstrate profound growth effects of green tea against Helicobacter and, importantly, demonstrate that green tea consumption can prevent gastric mucosal inflammation if ingested prior to exposure to Helicobacter infection. Research in the area of natural food compounds and their effects on various disease states has gained increased acceptance in the past several years. Components within natural remedies such as green tea could be further used for prevention and treatment of Helicobacter-induced gastritis in humans.

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  • Article: Coinfection modulates inflammatory responses and clinical outcome of Helicobacter felis and Toxoplasma gondii infections.
    Calin Stoicov, Mark Whary, Arlin B Rogers, Frederick S Lee, Kristine Klucevsek, Hanchen Li, Xun Cai, Reza Saffari, Zhongming Ge, Imtiaz A Khan, Crescent Combe, Andrew Luster, James G Fox, JeanMarie Houghton
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    ABSTRACT: The host immune response plays a critical role in determining disease manifestations of chronic infections. Inadequate immune response may fail to control infection, although in other cases the specific immune response may be the cause of tissue damage and disease. The majority of patients with chronic infections are infected by more than one organism yet the interaction between multiple active infections is not known, nor is the impact on disease outcome clear. Using the BALB/c strain of mice, we show that Toxoplasma gondii infection in a host infected with Helicobacter felis alters the natural outcome of T. gondii infection, allowing uncontrolled tachyzoite replication and severe organ damage. Survival rates decrease from 95% in T. gondii infection alone to 50% in dual-infected mice. In addition, infection with T. gondii alters the specific H. felis immune response, converting a previously resistant host to a susceptible phenotype. Gastric mucosal IFN-gamma and IL-12 were significantly elevated and IL-10 substantially reduced in dual-infected mice. These changes were associated with severe gastric mucosal inflammation, parietal cell loss, atrophy, and metaplastic cell changes. These data demonstrate the profound interactions between the immune response to unrelated organisms, and suggest these types of interactions my impact clinical disease.
    The Journal of Immunology 10/2004; 173(5):3329-36. · 5.79 Impact Factor
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

acid secretion
 
animal model
 
bacterial growth
 
bacterial overgrowth
 
bacteriostatic effect
 
common bacterial infections
 
gastric cancer
 
gastric mucosal inflammation
 
green tea consumption
 
H. pylori
 
Helicobacter felis
 
Helicobacter pylori bacterial factors
 
Helicobacter-induced gastritis
 
host genetics
 
humans
 
natural food compounds
 
natural remedies
 
profound growth effects
 
type 1 carcinogen
 
various disease states