Article

Early detection of patients in the pre demented stage of Alzheimer's disease: the Pre-Al Study.

INSERM U610 and AP-HP Fédération de Neurologie, Hôpital de la Salpétrière, Paris, France.
The Journal of Nutrition Health and Aging (impact factor: 2.69). 01/2009; 13(1):21-6. pp.21-6
Source: PubMed

ABSTRACT The aim of the Pre-Al study is to evaluate and compare the predictive value of different tools for an early identification of Alzheimer's disease.
Patients coming for consultation to memory clinics without dementia were included if they had an objective memory or attention trouble assessed by a MMSE score > 25 (with at least one missing item at the words recall) and / or an Isaac set test score < 28. All were examined by a neuropsychological battery (Free and Cued Selective Reminding Test, digit ordering test, WAIS-R digit symbol, Trail making test, Benton visual retention test, verbal fluency, confrontation naming and Baddeley's double task test). A subpopulation received an MRI and SPECT assessment.
251 patients were included (mean age: 72.0 years; mean education duration: 10.9 years). Validation of the predictive tests will be based on the comparison of these tests in patients developing dementia and others, after a follow-up of at least 3 years. This paper presents methodology of the study and the population description.

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    Article: A vitamin/nutriceutical formulation improves memory and cognitive performance in community-dwelling adults without dementia.
    A Chan, R Remington, E Kotyla, A Lepore, J Zemianek, T B Shea
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    ABSTRACT: Adults of both genders without dementia consumed a nutriceutical formulation ("NF," consisting of folic acid, B12, Vitamin E, S-adenosylmethionine, N-acetyl cysteine and Acetyl-L-carnitine), previously shown to improve cognitive performance in Alzheimer's disease, or placebo. Participants receiving NF but not placebo improved statistically and clinically in the California Verbal Learning Test II and the Trail-Making Test. Both groups improved further during a 3-month open-label extension. Additional individuals displayed identical improvement during a separate 6-month open-label trial. Performance declined to baseline following withdrawal of NF, and statistically improved when participants resumed taking NF. Additional participants receiving NF but not placebo demonstrated improvement within 2 weeks in Trail-making and Digit-Memory tests; both groups improved in a 2-week open-label extension. An increased percentage of participants > or = 74 years of age did not show improvement with NF, which may relate to age-related difficulties in adsorption and/or basal nutritional deficiencies, or age-related cognitive decline during the course of this study. These findings support the benefit of nutritional supplements for cognitive performance and suggest that additional supplementation may be required for the elderly.
    The Journal of Nutrition Health and Aging 01/2010; 14(3):224-30. · 2.69 Impact Factor
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

3 years
 
Alzheimer's disease
 
attention trouble
 
Baddeley's double task test
 
Benton visual retention test
 
Cued Selective Reminding Test
 
different tools
 
education duration
 
Free
 
neuropsychological battery
 
one missing item
 
others
 
paper presents methodology
 
population description
 
Pre-Al study
 
predictive tests
 
predictive value
 
SPECT assessment
 
verbal fluency
 
WAIS-R digit symbol