Article

[TGF-beta2 involvements in open angle glaucoma].

Clinica de Oftalmologie, Spitalul Clinic de Urgenţă Militar Central.
Oftalmologia (Bucharest, Romania: 1990) 02/2008; 52(3):110-2. pp.110-2
Source: PubMed

ABSTRACT To emphasize the correlation between TGF beta2 and primary open angle glaucoma (POAG).
Observational clinical study on two groups of patients: group I--17 patients with POAG who need surgical approach and group II--16 patients without glaucoma. The groups were homogeneous regarding age and sex. The exclusion criteria were any associated systemic pathology. The concentration of TGF beta2 in the aqueous humor of each patient of both groups was measured by ELISA method.
After the comparative analysis we observed that TGF beta2 was more increased in patients with POAG than in patients without the disease. The changes of trabecular extra cellular matrix are induced by many factors. TGF beta2 is a special cytokine witch is believed to increase the fibronectin concentration in the trabecular meshwork and alter the extra cellular matrix turn-over with a final profibrotic effect.

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Keywords

aqueous humor
 
comparative analysis
 
ELISA method
 
extra cellular matrix turn-over
 
fibronectin concentration
 
final profibrotic effect
 
Observational clinical study
 
patients
 
POAG
 
primary open angle glaucoma
 
special cytokine witch
 
surgical approach
 
TGF beta2
 
trabecular extra cellular matrix
 
trabecular meshwork