Interleukin-17A and interleukin-17F: a tale of two cytokines.

Children's Hospital of Pittsburgh, Rangos Research Center, Pittsburgh, PA 15201, USA.
Immunity (Impact Factor: 19.75). 02/2009; 30(1):9-11. DOI: 10.1016/j.immuni.2008.12.010
Source: PubMed

ABSTRACT In this issue of Immunity, Ishigame et al. (2009) show that interleukin-17A (IL-17A) mediates autoimmunity whereas both IL-17A and IL-17F are required for mucosal immunity. IL-17A may be more pathologic by inducing proinflammatory cytokines.

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