Article

Association of leptin with hemodialysis-related muscle cramps: a cross-sectional study.

Division of Nephrology, Hsinchu Branch of Cathay General Hospital, Taiwan, ROC.
Blood Purification (impact factor: 2.1). 02/2009; 27(2):159-64. DOI:10.1159/000190781 pp.159-64
Source: PubMed

ABSTRACT The mechanism of muscle cramp in hemodialysis patients is not well understood. Leptin, a middle molecule uremic toxin, is able to affect neuronal activity. This study aimed to determine the association between leptin and hemodialysis-related muscle cramps.
A total of 79 hemodialysis patients were enrolled. The episodes of hemodialysis-related muscle cramps were recorded over a 28-day period. Serum levels of leptin were measured on the 15th day, a mid-week dialysis session.
Frequent hemodialysis-related cramps were associated with old age and elevated serum leptin levels. The risk of frequent hemodialysis-related cramps increased with increasing tertiles of leptin concentration. This relationship remained significant after adjustment for age, mean ultrafiltration ratio, gender, body mass index, insulin, resistin, c-reactive protein, albumin, peripheral arterial disease, electrolytes, and beta(2)-microglobulin.
Leptin levels are associated with frequent hemodialysis-related cramps. Further studies are necessary to elucidate the underlying mechanisms.

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Keywords

79 hemodialysis patients
 
beta(2)-microglobulin
 
body mass index
 
c-reactive protein
 
elucidate
 
frequent hemodialysis-related cramps
 
hemodialysis patients
 
hemodialysis-related muscle cramps
 
leptin
 
leptin concentration
 
Leptin levels
 
mid-week dialysis session
 
middle molecule uremic toxin
 
neuronal activity
 
old age
 
peripheral arterial disease
 
serum leptin levels
 
Serum levels
 
ultrafiltration ratio
 
underlying mechanisms