Article

Increased IgG4 levels in children with autism disorder. Brain Behav Immun

Department of Medical Microbiology and Immunology, 2805, 50th Street, Wet lab building, Sacramento, CA 95817, USA.
Brain Behavior and Immunity (Impact Factor: 6.13). 03/2009; 23(3):389-95. DOI: 10.1016/j.bbi.2008.12.005
Source: PubMed

ABSTRACT Accumulating evidence indicates that immune dysfunction is associated with autism disorders in a significant subset of children. Previous reports have shown abnormal immunoglobulin (Ig) levels, including an increased presence of autoreactive antibodies in the circulation of individuals with autism. As IgG is the predominant antibody isotype in circulation, we expected that an altered immune response could result in an abnormal IgG subclass profile in children with autism. We examined circulating plasma levels of IgG1, IgG2, IgG3, and IgG4 in 241 children from the CHARGE (Childhood Autism Risks from Genetics and the Environment) study, a large epidemiologic case-control investigation, including 114 children who meet full criteria for autism disorder (AU), 96 typically developing control children (TD) from a randomly selected sample of the general population, and 31 children with developmental delays (DD). We report significantly increased levels of the IgG4 subclass in children with AU compared with TD control children (p=0.016) and compared with DD controls (p=0.041). These results may suggest an underlying immunological abnormality in AU subjects resulting in elevated IgG4 production. Further investigation is necessary to elucidate the relationship between immunological findings and behavioral impairments in autism.

Download full-text

Full-text

Available from: Charity E Onore, Aug 16, 2015
1 Follower
 · 
133 Views
    • "Both long-term and short-term exposures to ambient air pollutants have been shown to stimulate oxidative stress and inflammation in humans, which may also affect neurologic development (Block and Calderon-Garciduenas, 2009; Calderon-Garciduenas et al., 2009). Studies have also shown that inflammation may contribute to the pathogenesis of ASD (Enstrom et al., 2009; Li et al., 2009). Thus, inflammation may serve as a link between ASD risk and ambient air pollutant exposure . "
    [Show abstract] [Hide abstract]
    ABSTRACT: Prenatal and perinatal exposures to air pollutants have been shown to adversely affect birth outcomes in offspring and may contribute to prevalence of autism spectrum disorder (ASD). For this ecologic study, we evaluated the association between ASD prevalence, at the census tract level, and proximity of tract centroids to the closest industrial facilities releasing arsenic, lead or mercury during the 1990s. We used 2000 to 2008 surveillance data from five sites of the Autism and Developmental Disabilities Monitoring (ADDM) network and 2000 census data to estimate prevalence. Multi-level negative binomial regression models were used to test associations between ASD prevalence and proximity to industrial facilities in existence from 1991 to 1999 according to the US Environmental Protection Agency Toxics Release Inventory (USEPA-TRI). Data for 2489 census tracts showed that after adjustment for demographic and socio-economic area-based characteristics, ASD prevalence was higher in census tracts located in the closest 10th percentile compared of distance to those in the furthest 50th percentile (adjusted RR=1.27, 95% CI: (1.00, 1.61), P=0.049). The findings observed in this study are suggestive of the association between urban residential proximity to industrial facilities emitting air pollutants and higher ASD prevalence. Copyright © 2015 Elsevier B.V. All rights reserved.
    Science of The Total Environment 07/2015; 536:245-251. DOI:10.1016/j.scitotenv.2015.07.024 · 4.10 Impact Factor
  • Source
    • "。 与 IL-4 一样,IFN-γ 不穿过胎盘,产妇血清水平与 胎儿暴露于细胞因子的关系也尚不清楚。 3 免疫球蛋白 与 ASD 中 B 细 胞 的 变 化 一 样,ASD 中 免 疫 球蛋白水平的研究结果亦不一致。有研究发现孤 独症患儿血清 IgG 的一个亚型 IgG4 显著增加,而 IgG1、IgG2、IgG3 没有改变 [36] "
    [Show abstract] [Hide abstract]
    ABSTRACT: Autism spectrum disorders (ASD) are a group of neuro-developmental disorders in early childhood which are defined by social difficulties, communication deficits and repetitive or restrictive interests and behaviours. The etiology of ASD remains poorly understood. Much research has shown that children with ASD suffer from immunological dysfunction. This article reviews the current research progress on immunological dysfunction in children with ASD, including abnormalities in immune cells, antibodies, complements, cytokines, major histocompatibility complex and their potential association with ASD, and explores the impacts of maternal immunological activation on the immune dysfunction of children with ASD.
  • Source
    • "Numerous studies have described the immunological disturbances in ASD patients; one study determined an imbalance the T-helper (Th)1/Th2 subsets toward Th2 in autistic children, implying a predisposition to allergic and autoimmune disorders and a decreased ability to combat infections (Cohly & Panja, 2005). Evidence has also suggested alterations in the pattern of the serum immunoglobulin (Ig) subclass profile, such as increased serum IgE (Magalhaes et al., 2009; Mostafa, Hamza, & El- Shahawi, 2008) and IgG4 subclass levels (Enstrom et al., 2009) in ASD patients. Moreover, in the National Survey of Children's Health in the United States, the parents of autistic children reported more allergy symptoms than did those of healthy controls (Gurney, McPheeters, & Davis, 2006). "
    [Show abstract] [Hide abstract]
    ABSTRACT: Previous research has suggested an association between autism spectrum disorder (ASD) and allergic disorders, but epidemiological evidence regarding asthma remains limited. We conducted a nationwide population-based prospective cohort study (1:4 case:control patients, age- and gender-matched), hypothesizing that asthma in infancy or toddlerhood increased the risk of ASD. The participants comprised 2134 asthmatic infants and children and 8536 controls aged 0–3 years in 2002. We identified cases of ASD that occurred near the end of the follow-up period (December 31, 2010), determining that asthmatic infants and children exhibited a higher accumulative incidence rate of ASD than did the controls (1.3% vs 0.7%, P = .007). After adjusting for age at enrollment, gender, level of urbanization, and comorbid allergic diseases (i.e., allergic rhinitis and atopic dermatitis), asthmatic infants and children exhibited an elevated risk of developing ASD (hazard ratio: 2.01, 95% confidence interval: 1.19–3.40). This prospective study indicated a temporal relation between asthma and subsequent ASD diagnosis, supporting the immune hypothesis of ASD pathogenesis. Further studies are required to clarify the probable interactional effects between these disorders and define a homogenous ASD subgroup.
    Research in Autism Spectrum Disorders 04/2014; 8(4):381–386. DOI:10.1016/j.rasd.2013.12.022 · 2.96 Impact Factor
Show more

Similar Publications