Aryl sulphonyl amides as potent agonists of the growth hormone secretagogue (ghrelin) receptor.
Department of Medicinal Chemistry & DMPK, Neurology & GI Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK.Bioorganic & medicinal chemistry letters (Impact Factor: 2.65). 01/2009; 19(3):684-7. DOI: 10.1016/j.bmcl.2008.12.042
ABSTRACT As part of an on-going lead optimisation effort, a cross screening exercise identified an aryl sulphonyl amide hit that was optimised to afford a highly potent series of ghrelin receptor agonists.
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