Sympathetic Skin Responses Evoked by Different Stimuli Modalities in Spinal Cord Injury Patients
Department of Neurology and Neurorehabilitation, Instituto Guttmann, Badalona, Barcelona, Spain. Neurorehabilitation and neural repair
(Impact Factor: 3.98).
02/2009; 23(6):553-8. DOI: 10.1177/1545968308328721
By using a combination of physiological and electrical peripheral nerve stimuli, the authors aimed to characterize the expected dysfunction of the circuits responsible for sympathetic skin response (SSR) in persons with spinal cord injury (SCI).
The authors examined SSR induced in the hand and foot in 50 SCI patients and 15 age-matched and gender-matched healthy volunteers. SSR was induced by deep inhalation, unexpected acoustic stimuli, brisk hand muscle contraction, and median and peroneal nerve electrical stimulation (PNS).
SSRs to any stimulus modality were absent in hand and foot in patients with complete SCI above the T4 level. They were present in the hand and absent in the foot in complete SCI patients at levels between T4 and T11 for all stimuli modalities except PNS. The elicitability of SSR was lower with peroneal nerve stimulation than the other stimuli in hand and foot. The mean latency difference between SSRs of the hand and foot was significantly longer in patients than in controls, regardless of stimulus modality. The amplitude of SSR was larger in volunteers than in patients.
SSR to various stimuli confirms the importance of supraspinal centers and the integrity of sympathetic descending pathways. Simultaneous recording of the SSR in the hands and feet provides information about the degree of sympathetic impairment possibly in the efferent pathway. To monitor spontaneous recovery or the efficacy of a drug or biological therapeutic intervention, changes in the latency delay between the hand and foot may be valuable.
Available from: onlinelibrary.wiley.com
- "To improve the quality of life in SCI patients, several surgical approaches have been used to overcome detrusor-sphincter dyssynergia (DSD). Deafferentation of the sacral roots by dorsal rhizotomy, coupled with ventral roots stimulation either intradurally or extradurally (Brindley et al., 1982; Kumru et al., 2009), has been applied successfully in the treatment of suprasacral spastic neurogenic bladder, especially when associated with SCI (Mayer and Howard, 2008). However, because of complicated nerve anatomy in human, accidental loss of superficial and deep sensation of the perineum, as well as loss of the erectile function can occur during the sacral posterior rhizotomy (SPR). "
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ABSTRACT: It is known that selective sacral roots rhizotomy is effective for relieving the neurogenic bladder associated with spinal cord injury. The goal of this study is to review the surgical anatomy of the lumbosacral nerve rootlets and to provide some morphological bases for highly selective sacral roots rhizotomy. Spinal cord dissections were performed on five cadavers under surgical microscope. At each spinal cord segment, we recorded the number, diameter and length of the rootlets, subbundles and bundles from the L1 to S2 spinal segments, and the length of the dorsal/ventral root entry zone. Peripheral nervous system myelin was examined by immunohistochemistry. We found: (1) the ventral or the dorsal root of the lumbosacral segment of the spinal cord was divided into one to three nerve bundles and each bundle was subdivided into one to three subbundles. Each subbundle further gave out two to three rootlets connected with the spinal cord; (2) there were no significant differences in the number of rootlets within the L1 to S2 segments, but the size of rootlets and the length of nerve roots varied (P < 0.05); and (3) the more myelinated fibers a rootlet contained, the larger transection area it had. The area of peripheral nervous system myelin positive cells and the total area of rootlets were correlated (P < 0.001). Thus, during highly selective sacral roots rhizotomy, the ventral and dorsal roots can be divided into several bundles of rootlets, and we could initially distinct the rootlets by their diameters.
The Anatomical Record Advances in Integrative Anatomy and Evolutionary Biology 12/2010; 293(12):2123-8. DOI:10.1002/ar.21213 · 1.54 Impact Factor
Available from: Timothy K. Shih
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ABSTRACT: Digital inpainting is an image interpolation mechanism, which can automatically restore damaged or partially removed image. Most inpainting mechanisms use a singular resolution approach on the extrapolation or interpolation of pixels. We propose a multi-resolution algorithm, which can take into consideration the different levels of details. The algorithm was tested on 1000 still images, with an evaluation showing the effectiveness of our approach. The demonstration of our work is available at: http://www.mine.tku.edu.tw/demos/inpaint.
Multimedia and Expo, 2003. ICME '03. Proceedings. 2003 International Conference on; 08/2003
Available from: Chunmin Liang
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ABSTRACT: The chemokine receptor CCR7 is highly expressed in dendritic cells (DCs), T cells, and other immune effector cells. One of the high-affinity ligand that can bind to CCR7 is the secondary lymphoid tissue chemokine (SLC). The SLC/CCR7 axis plays an important role in the immune system by inducing the chemotaxis and migration of immune effector cells. In this study, we examined the effect of SLC at different concentrations (0, 50, 100, 200, 300, and 400 ng/mL) on the proliferation of bone-marrow-derived dendritic cells (BMDCs). ELC (CCL19), another high-affinity ligand for CCR7, was used as the control at the same time. We found that SLC directly stimulated the proliferation of BMDCs and enhanced the antigen-presenting function and CCR7 expression. Western blot analysis showed that pNF-kappaBp65 was involved in this mechanism. We also found that the NF-kappaB inhibitor PDTC could specifically block the proliferation and CCR7 expression of BMDCs induced by SLC or ELC (200 ng/mL). The results suggested that there were cross-talk signals between the chemotaxis and proliferation of BMDCs involving the SLC/CCR7 axis.
The Anatomical Record Advances in Integrative Anatomy and Evolutionary Biology 01/2010; 293(1):48-54. DOI:10.1002/ar.21015 · 1.54 Impact Factor
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