Hallazgos anatomopatológicos en equinos y mulares de la región patagónica, afectados de mal seco



SUMMARY PATHOLOGICAL FINOINGS IN HORSES ANO MULES WITH "MAL SECO", A GRASS SICKNESS-LIKE SYNOROME, IN PATAGONIA REGION, ARGENTINA- Mal seco is a disease that affects horses and mules grazing in the Patagonia region of Argentina. Seven horses and two mules were necropsied and histopathological studies carried out. The digestive tract presented the most striking findings. The stomach was distended with a fetid. greenish fluid. The large colon. and in some cases the caecum. were dilated by a large amount of dry. impacted, acid smelling. dark-coated contents, resembling a stack of coins. Foca' necrosis of the epithelium with bacterial colonization was consistently found in oesophagus, stomach, small intestine and large intestine. Loss of basophilia. margination of nuclei and a rounded outline to the neuronal body was observed in neurones of the ventral horn of the spinal cord. Slight demyelination was also observed in the spinal cord. The information gained in this study compared with that reported previously by the authors. provide support to the suggestion that Mal seco and Grass sickness are similar diseases.

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    ABSTRACT: 'Mal seco' is a grass sickness-like syndrome of horses in Argentina. A histopathological study was made of the coeliaco-mesenteric ganglia of four horses with 'mal seco' and of four horses that died from other causes. The severity and extent of the lesions found in the horses with 'mal seco' was greatest in the two with the shortest clinical course. Degenerative changes consisted mainly in the loss of Nissl substance, cytoplasmic vacuoles, neuronophagia, intercellular and intracytoplasmic eosinophilic bodies, and pyknotic and eccentric nuclei. The coeliaco-mesenteric ganglia of the control horses had no histological lesions. The histological lesions in the horses with 'mal seco' were very similar to those described in the coeliaco-mesenteric ganglia of horses with grass sickness in Europe and it is suggested that 'mal seco' and grass sickness may be the same disease.
    The Veterinary record 04/1992; 130(12):244-6. DOI:10.1136/vr.130.12.244 · 1.49 Impact Factor
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    ABSTRACT: Pathological examinations were made on 6 horses with clinical grass sickness. Support for the diagnosis was obtained in 5 cases, in 4 of which chromatolysis and necrosis of neurons in specific regions of the central nervous system were also found. The local severity of these lesions appeared to be directly proportional to the duration of clinical illness. As the distribution of the lesions indicates a possible relationship to the parasympathetic division of the autonomic nervous system it is tentatively suggested that these changes in the central nervous system may be of direct significance in the pathogenesis of grass sickness.
    Journal of Comparative Pathology 08/1969; 79(3):407-11. DOI:10.1016/0021-9975(69)90059-0 · 1.14 Impact Factor