Biologic keratoprosthesis materials.
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ABSTRACT: In the present study, novel biomimetic composite scaffolds with a composition similar to that of natural bone were prepared, using nano-hydroxyapatite, collagen, and phosphatidylserine. The scaffolds possess an interconnected porous structure with a porosity of 84%. The pore size ranges from several micrometers up to about 400 μm. In-vitro studies in simulated body fluids showed that the morphologies of the products derived from mineralization can be regulated by the extracellular matrix components of the scaffolds; this in turn leads to creation of a large number of hydroxyapatite crystals on the scaffold surface. The regulatory properties of collagen and phosphatidylserine also influenced the cell response to the composite scaffolds. MC3T3-E1 cells attached and spread on the surfaces of the materials and interacted with the substrates; this may be the result of charged groups on the composite materials. Radiological analysis suggested that calluses and bone bridges formed in defects within 12 weeks. These composite scaffolds may therefore be a suitable replacement in bone-tissue engineering.Chinese Science Bulletin 07/2012; 57(21). DOI:10.1007/s11434-012-5201-4 · 1.37 Impact Factor
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ABSTRACT: Glaucoma drainage devices are more frequently being used for glaucoma filtering surgeries, even those at low risk for failure with trabeculectomy. There are 4 major devices available: the Molteno, Baerveldt, Krupin, and Ahmed. The Molteno and Baerveldt are non-valved implants, while the Krupin and Ahmed are valved. The success rates of the different valves are about equal at approximately 70% with a mean intraocular pressure (IOP) lowering of at least 50% from the pre-operative IOP. Unfortunately, the failure rate is about 10% per year, leading to only 50% functional drainage devices at 5 years. Therefore, research on the biomaterials, shape, and technique of drainage implant surgery is being done in hopes of increasing long term success rates.Seminars in ophthalmology 11/2010; 25(5-6):265-70. DOI:10.3109/08820538.2010.518840 · 1.20 Impact Factor
Article: The Boston keratoprosthesis.International ophthalmology clinics 01/2010; 50(3):161-75. DOI:10.1097/IIO.0b013e3181e20cca