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Mecanismos de acción de la inmunoglobulina humana en las enfermedades dermatológicas pediátricas

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    ABSTRACT: Caso clínico Revista Alergia México 2005;52(1):39-41 RESUMEN Se reporta el caso de una paciente joven, con pénfigo vulgar, de afectación mucocutánea, recalcitrante, con múltiples complicaciones, secundarias al uso crónico de corticoesteroides, y mielosupresión por azatioprina. Se le trató con dosis altas de inmunoglobulina humana intravenosa durante cinco días consecutivos y en tres semanas se logró la remisión total de las lesiones ampollosas. Por lo tanto, la inmunoglobulina intravenosa se considera una buena alternativa para el manejo del pénfigo vulgar, cuando no exista respuesta al trata-miento o se hayan manifestado complicaciones como consecuencia del uso prolongado de altas dosis de corticoesteroides. Palabras clave: pénfigo vulgar, inmunoglobulina intravenosa. ABSTRACT A case of a young woman with recalcitrant pemphigus vulgaris involving skin and mucosae, with multiple side effects due to the chronic use of corticosteroids and azathioprine related myelosuppression is presented. She received high doses of intravenous immunoglobulin for five consecutive days and showed a rapid disease control, with healing in three weeks. Remission observed in this patient supports the idea that intravenous immunoglobulin is a good alternative of treatment for patients with pemphigus vulgaris, when there is no response to it or when significant adverse effects appear as a result of its prolonged use.

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