Article

Disturbo Affettivo Stagionale e Sindrome Premestruale Seasonal Affective Disorder and Premenstrual Syndrome

ABSTRACT Summary Objective It has been accepted, since ancient times that seasonal environmental changes affect human behaviour and mood. Modern psychiatric research has proved the existence of pathological chronobi- ological factors. One of the main features in such disorders is the cyclical pattern, such as the well-known Seasonal Affective Disorder (SAD) first described by Rosenthal in the 80's. Of the cyclical disorders, the Premenstrual Syndrome (PMS) shows clinical analogies compared with Seasonal Affective Disorder. Aim of the study is to: a. evaluate the prevalence either of the Seasonal Affec- tive Disorder and of the Premenstrual Syndrome in a sample of women unaffected by psychiatric disturbances, and b. evaluate the statistical prevalence of the Premenstrual Syndrome in a sub-group of women with a diagnosis of Seasonal Affective Disorder and the probability of association between the two disturbances, if any. Methods

0 Bookmarks
 · 
44 Views
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The Seasonal Pattern Assessment Questionnaire (SPAQ) was mailed to a sample population balanced for sex and randomly selected from local telephone directories in four areas: Nashua, NH, New York, NY, Montgomery County, MD, and Sarasota, FL. On the basis of responses to this questionnaire, prevalence rates of winter seasonal affective disorder (winter SAD), summer seasonal affective disorder (summer SAD), and subsyndromal winter SAD were estimated for the four areas. Rates of winter SAD and subsyndromal SAD were found to be significantly higher at the more northern latitudes, while no correlation was found between latitude and summer SAD. The positive correlation between latitude and prevalence of winter SAD applied predominantly to the age groups over 35.
    Psychiatry Research 03/1990; 31(2):131-44. · 2.68 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Seasonal affective disorder (SAD) and premenstrual dysphoric disorder (PMDD) share many clinical features, and have been associated with brain serotonin dysfunction. Females with SAD frequently fulfil the diagnostic criteria for PMDD. A polymorphism in the serotonin transporter promoter gene (5-HTTLPR) has been associated with SAD. We investigated the role of family history and 5-HTTLPR in female SAD patients with and without PMDD. Forty-four SAD females with, and 43 SAD females without PMDD, were genotyped for 5-HTTLPR. Family history of affective disorders in first degree relatives was assessed. An association between the presence of PMDD and family history (P=0.0029) and 5-HTTLPR long/short allele-heterozygosity (P=0.033) was found in females with SAD. PMDD and SAD may share genetic vulnerability factors, one candidate gene being 5-HTTLPR. The elevated rate of affective disorders in relatives of patients with SAD and PMDD suggests higher genetic vulnerability in this subgroup when compared to patients with SAD alone.
    European Neuropsychopharmacology 05/2002; 12(2):129-34. · 4.60 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: The present study extends a previous report of lower plasma ACTH levels in women with premenstrual syndrome (PMS) compared with asymptomatic controls. Plasma levels of estradiol and progesterone were measured daily in 10 women with confirmed PMS and 8 asymptomatic women. Daily symptom reports were maintained during the same menstrual cycle. Both estradiol and progesterone levels were consistently, but not significantly, higher throughout the cycle in PMS subjects compared with controls. From the follicular to the early luteal phase, estradiol levels were significantly higher in a previously defined PMS subgroup 2 with more severe symptoms throughout the cycle compared with both the less severe PMS subgroup 1 and controls. Progesterone levels were significantly and positively correlated with PMS symptoms along the entire menstrual cycle, preceding the symptoms by 5-7 days. These preliminary results provide support for the hypothesis that the presence of progesterone at early luteal phase levels is required for PMS symptoms to occur.
    Psychoneuroendocrinology 02/1995; 20(3):259-67. · 5.59 Impact Factor

Full-text

Download
2 Downloads
Available from
Oct 22, 2014