Angioma en penacho (angioblastoma de Nakagawa). Consideraciones sobre la influencia de las hormonas sexuales femeninas en su evolución Tufted angioma. Consideration of the influence of female sexual hormones in its evolution


Summary Tufted angioma is a benign slow progressing tumour that affects mainly children and young adults. It appears frequently before the age of 5 years. Its clinical appearence is as macule, papule, plaque or nodule; skin coloured, erithematous, bluish, and localizes usually in the face, neck, shoulders or upper part of the chest. Local hyperhidrosis, infiltration, increased temperature, telangiectasies and petechias may be observed. Other important clini- cal manifestations include pruritus and/or pain. Tufts of capilar vessels in the dermis or subcutis is the main histological feature. The light of these ves- sels is reduced, rounded by colagen, giving the appearence of cannon bullet. Two female patients with diagnosis of tufted angioma whose evolution were significantly affected by hormonal changing situations are reported. We theorize about the possible rol of female sexual hormones in the growing of this angioblastoma.

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    ABSTRACT: Tufted angioma is a rare acquired cutaneous angiomatous proliferation characterized by slowly spreading erythematous macules and plaques, sometimes surmounted by nodular formations. Synonyms are progressive capillary hemangioma and Nakagawa's angioblastoma. Tufted angioma appears to be benign since follow-up studies did not report malignant transformation. This lesion must be distinguished from other vascular tumors, especially from Kaposi's sarcoma. If this lesion appears in an older patient, angiosarcoma should be excluded.
    Dermatology 02/1997; 194(4):402-4. DOI:10.1016/0926-9959(95)96556-N · 1.57 Impact Factor
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    ABSTRACT: Tissues from a two-month-old Japanese male infant with a typical angioblastoma of the skin on the right groin was examined by light and electron microscopy before and after soft X-ray therapy. Before therapy, nest-like proliferation of the tumor cells with frequent formation of vascular spaces was observed. Ultrastructurally, these tumor cells showed the morphological characteristics of vascular endothelial cells in their size, shape and usual organelles. These cells usually had an abundance of peculiar dense granules with a limiting membrane. Fibrin deposits and thrombosis with aggregations of platelets were observed in the lumina in situ. After soft X-ray therapy with a total dose of 3,600 rads, disappearance of most of the tumor cell-nests and prominent dilatation of the residual vessels were observed. Ultrastructurally, numbers of the vessels showed more or less degenerative and destructive changes. Vessels with ruptured endothelial cell linings, extravasated red cells, and hemosiderin deposits were also frequently observed. From these findings, it is concluded that angioblastoma of the skin should be considered as one of the benign hemangiomas of the skin, and that degenerative changes in the endothelial cells induced by irradiation are almost identical to those in other conditions.
    The Journal of Dermatology 07/1981; 8(3):235-43. DOI:10.1111/j.1346-8138.1981.tb02540.x · 2.25 Impact Factor
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