Etiology of Viral Gastroenteritis in Children < 5 Years of Age in the United States, 2008-2009

Gastroenteritis and Respiratory Viruses Laboratory Branch, Division of Viral Diseases, National Center for Immunizations and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, GA.
The Journal of Infectious Diseases (Impact Factor: 5.85). 06/2013; 208(5). DOI: 10.1093/infdis/jit254
Source: PubMed

ABSTRACT Background. Although rotavirus and norovirus cause nearly 40% of severe endemic acute gastroenteritis (AGE) in children <5 years of age in the United States (US), there are limited data on the etiologic role of other enteric viruses in this age group.Methods. We conducted active population-based surveillance in children presenting with AGE to hospitals, emergency departments, and primary care clinics in three US counties. Stool specimens from these children and from age-matched healthy controls collected between October 2008 and September 2009 were tested for enteric adenovirus, astrovirus, sapovirus, parechovirus, bocavirus and aichivirus. Typing was carried out by sequencing and phylogenetic analysis.Results. Adenovirus, astrovirus, sapovirus, parechovirus, bocavirus and aichivirus were detected in the stool specimens of 11.8%, 4.9%, 5.4%, 4.8%, 1.4% and 0.2% of AGE patients and 1.8%, 3.0%, 4.2%, 4.4%, 2.4% and 0% of healthy controls, respectively. Adenovirus [type-41], astrovirus [types-1, 2, 3, 4, 8], sapovirus [GI and GII], parechovirus [types-1, 3, 4, 5] and bocavirus [types-1, 2, 3] were found co-circulating.Conclusions. Adenovirus, astrovirus, and sapovirus infections were detected in 22.1% of the specimens from children <5 years of age who had medical visits for AGE and tested negative for rota- and norovirus. No causal role for parechovirus and bocavirus was found.

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Jun 1, 2014