Study of the Concentration of Trace Elements Fe, Zn, Cu, Se and Their Correlation in Maternal Serum, Cord Serum and Colostrums

DOI: 10.1007/s12291-013-0338-8

ABSTRACT A study of iron, zinc, copper and selenium concentration levels was carried out in three compartments namely, maternal serum (MS), colostrums and cord blood serum (CS) of healthy Indian mothers (n = 42) who delivered healthy normal neonates without any congenital anomalies at Bhabha Atomic Research Centre hospital, Mumbai. Fe, Zn, Cu in maternal serum, cord blood and colostrums were estimated by flame atomic absorption spectrometry while Se was determined by graphite furnace absorption spectrometry. It was seen that there was a significant difference in the level of trace elements in the three compartments. The average levels of Fe in the three compartments were 1,132 ± 519, 2,312 ± 789 and 1,183 ± 602 μg/L while Zn was 514 ± 149, 819 ± 224 and 7,148 ± 2,316 μg/L respectively. Mean Cu values were 1,614 ± 295, 301 ± 77 and 392 ± 174 μg/L respectively while Se values were 70 ± 15, 36 ± 10 and 23 ± 8 μg/L respectively. The results indicated a positive correlation of Fe and Zn concentrations in MS versus CS which were (r = 0.386), (r = 0.572) respectively and Fe levels in MS and colostrums (r = 0.235). A few inter element correlations were found within compartments. Zn and Se showed a negative correlation in both MS (r = −0.489) and colostrums (r = −0.258) while a positive inter correlation of Fe and Zn was seen in MS (r = 0.44) and in CS (r = 0.54). This study gave us an overview of the serum and colostrum values of mother and neonates in Indian population, data of which are scarce.

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    ABSTRACT: Pregnancy is associated with increased demand of all the nutrients like Iron, Copper, Zinc etc. and deficiency of any of these could affect pregnancy, delivery and out come of pregnancy. With this consideration, the study was conducted on 80 mothers and newborns and 20 age matched control women. Out of 80 mothers, 34 had Iron deficiency anemia and their Hb levels were below 9.0 gm/d(1). Pregnant women had significantly lower Iron and Zinc levels while Copper and Total Iron Binding Capacity (TIBC) were significantly higher (P<0.001). Newborns had significantly elevated Iron and Zinc levels and low levels of Copper and TIBC as compared to their mothers irrespective of Iron deficiency anemia. Micronutrient status of newborn was found to be dependent on their mother's micronutrient status. Besides, results also suggest micronutrient interactions, which are reflected in Iron/Zinc, Iron/Copper and Zinc/Copper ratios. In view of this, there is need for proper, adequate and balanced micronutrient supplementation during pregnancy to affect a healthy outcome.
    Indian Journal of Clinical Biochemistry 07/2004; 19(2):48-52.
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    ABSTRACT: Breast milk has unique properties; one is the variability of the compounds in ratio according to the baby's needs for every lactation period. Iron and zinc are essential elements for life. The aim of this study is to determine Fe and Zn levels in plasma and breast milk of mothers through the first 4 months after delivery and to evaluate its relation with infants' growth and immune system functions. The study conducted through January 2000 - April 2001 in Bursa with 27 mother-infant couples. The babies grouped into two: Group 1 (n: 16) was formed by the breast milk fed babies, and Group 2 (n: 11) included the babies fed with both breast milk and formula. Besides clinical assessment of the babies, laboratory evaluations were performed on the sera of couples and breast milk. While the comparison of Zn level in colostrum with mature and late mature breast milk demonstrated a statistical significance (p0.05). Our study affirms the suggestion for Fe supplementation for healthy, term infants beginning from 4 th month regardless of nutritional model. The results of the surveillance studies demonstrated that approximately 22% of children less than 2 years suffered from anemia due to iron deficiency with an increasing prevalence among cow milk fed infants. Inadequate intake of iron during infancy leads to impaired cognitive development, and zinc deficiency is associated with acrodermatitis, failure to thrive, irritability, impaired neurological functions, and intractable
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    ABSTRACT: Using inductively coupled plasma mass spectrometry (ICP-MS) based analytical procedures, the concentration of several trace elements (Mn, As, Pb, Co, Ni, Cu, Zn and Se) was determined in human milk samples collected from a group of healthy lactating Portuguese women (n=44), both on the 2nd day postpartum (i.e., colostrum; n=34) and at 1 month postpartum (i.e., mature milk; n=19). Blood samples (n=44), collected on the 2nd day after parturition, were also analyzed for the same trace elements. No major correlations were observed between the levels of the analyzed trace elements in blood and colostrum samples. All the studied elements, except for Co, Pb and Ni, showed a significant trend for a decrease in concentration in milk during the first month of lactation. This trend was more pronounced for Zn and Se, whose levels decreased to approximately 23% and 44% of their initial mean concentration, respectively. With the exception of Co (r=0.607) and Zn (r=0.487), no significant correlations were observed when comparing the levels of each trace element between samples of colostrum and mature milk. Several inter-element correlations were found within each type of milk sample. The most significant were: (i) Se vs Cu (r=0.828) and Se vs Co (r=0.605) in colostrum samples and (ii) Ni vs Pb (r=0.756), Ni vs Mn (r=0.743) and Se vs Co (r=0.714) in mature milk samples. An inverse correlation between Zn and Se was also found in both types of milk sample; however, it only reached statistical significance for mature milk (r=-0.624).
    Journal of Trace Elements in Medicine and Biology 02/2008; 22(3):196-205. · 1.96 Impact Factor


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May 31, 2014