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Infective endocarditis in a dog and the phylogenetic relationship of the associated "Bartonella rochalimae" strain with isolates from dogs, gray foxes, and a human

Napa County Health and Human Services, Public Health Division, 2344 Old Sonoma Rd., Bldg. G, Napa, California 94559, USA.
Journal of clinical microbiology (Impact Factor: 4.23). 03/2009; 47(3):787-90. DOI: 10.1128/JCM.01351-08
Source: PubMed

ABSTRACT The first case of canine endocarditis caused by "Bartonella rochalimae" is reported. By PCR-restriction fragment length polymorphism, sequence, and phylogenetic analyses, Bartonella isolates from a dog with endocarditis, 22 gray foxes, and three dogs, described as B. clarridgeiae like, were confirmed to belong to the new species "B. rochalimae," suggesting canids as the natural reservoir.

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    • "Similarly, Bartonella bovis, for which cattle are the primary reservoir hosts, has been reported to cause endocarditis in older dairy cattle (Maillard et al., 2007). Pre-existing heart valve pathology, therapeutic suppression of the immune system or immune senescence with ageing appear to be common risk factors among animals and people for the development of Bartonella endocarditis (Fenollar et al., 2005; Houpikian and Raoult, 2005; Varanat et al., 2009; Henn et al., 2009; Fournier et al., 2010). In Fig. 1, endocarditis associated with B. henselae infection in a human patient is compared with the endocarditis in a dog, only in association with B. vinsonii subsp. "
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    • "The present study, although limited in size, demonstrates a difference in susceptibility among domestic dogs, cats, and guinea pigs to experimental infection with a human isolate of B. rochalimae. To date, isolates of this new Bartonella species have been cultured from mammals in the new world, including from a human who traveled to South America [9], and from gray foxes, raccoons, coyotes and domestic dogs in California [11] [12]. In addition , B. rochalimae has been cultured from a red fox (Vulpes vulpes) from France 1 and a strain closely related to B. rochalimae was recently isolated from a rat in Taiwan [15]. "
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