Genome-Wide Association Studies of Serum Magnesium, Potassium, and Sodium Concentrations Identify Six Loci Influencing Serum Magnesium Levels

Human Genetics Center and Division of Epidemiology, The University of Texas Health Science Center at Houston, School of Public Health, Houston, Texas, USA.
PLoS Genetics (Impact Factor: 7.53). 08/2010; 6(8). DOI: 10.1371/journal.pgen.1001045
Source: PubMed


Magnesium, potassium, and sodium, cations commonly measured in serum, are involved in many physiological processes including energy metabolism, nerve and muscle function, signal transduction, and fluid and blood pressure regulation. To evaluate the contribution of common genetic variation to normal physiologic variation in serum concentrations of these cations, we conducted genome-wide association studies of serum magnesium, potassium, and sodium concentrations using ~2.5 million genotyped and imputed common single nucleotide polymorphisms (SNPs) in 15,366 participants of European descent from the international CHARGE Consortium. Study-specific results were combined using fixed-effects inverse-variance weighted meta-analysis. SNPs demonstrating genome-wide significant (p

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    • "Furthermore, these SNPs may be responsible for a higher likelihood of developing gestational diabetes mellitus (Nair et al. 2012). Genomewide association studies with more than 15,000 individuals of European descent showed that rs11144134 in TRPM6 is associated with lower serum Mg 2+ levels (Meyer et al. 2010). Recently, genome-wide association studies to link Mg 2+ intake and fasting glucose and insulin levels were carried out in more than 50,000 healthy Europeans (Hruby et al. 2013). "
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