Emerging of Mycotic Infection in Patients Infected with Mycobacterium tuberculosis

World Journal of Medical Sciences 01/2008; 3 (2)(3 (2)):74-80.

ABSTRACT In 21st century, the load of opportunistic infections will increase tremendously due to increase in
immunocompromising capacity of host particularly in patients suffering from cancer, AIDS and tuberculosis.
Therefore, optimal management of opportunistic fungal infections is indispensable. Tuberculosis patients are
immunocompromsed and they take prolong treatment of antibiotic and vitamins tablets i.e. immunosuppressive
agents hence fungal infection occurs in early stages of infection. But doctors and physicians prescribe only
antibacterial drugs, so patients require for cure more time due to infection of fungus. But some patients are
those whose sputum examination is negative but x-rays reports are positive and persists symptoms of
tuberculosis, in their lungs there are cavities or opacity, which may be due to opportunistic fungal infection.
The present study aims to relate the opportunistic fungal pathogens, their infections and identification of such
fungi that are present in pulmonary tuberculosis patients, which may help in correct diagnosis of these
diseases. Confirmed tuberculosis by sputum examination in ten laboratories of washim district, Maharashtra,
India. Culture characteristic of defferent fungi analysis were done using sputum sample of chronic tuberculosis
patients and symptomatic patients (Non tuberculosis). In our survey in different hospitals and primary health
center of Washim District (Central India) under the Revised National Tuberculosis Control Programmed
(RNTCP) of World Health Organization, 1357 patients of tuberculosis were recorded during June 2002 to
September 2003 by sputum examination in ten laboratories of tuberculosis in Washim district of Maharashtra,
India. These patients were classified age-wise. The maximum patients were recorded between the age of 35 to
45 years and old patients suffering for mycotic infection. Percentage of male patients was more as compared
to female. Highly pulmonary tuberculosis patients 500 out of the 203 patients were suffering from mycotic
infection. The percentage of mycotic infections in pulmonary tuberculosis patients was 46%. Mainly four types
of fungi, i.e. Aspergillus niger, A. fumigatus, Histoplasma capsulatum and Cryptococcus neoformans were
recorded, which causes severe infection in lungs in patients suffering from pulmonary tuberculosis. The
increasing presence of overlapping opportunistic infections in tuberculosis, identification of such fungi that
are present in pulmonary tuberculosis patients. Which may help in correct diagnosis of these diseases.So that
cure rate will be increase
Key words: Opportunistic mycotic infection Pulmonary tuberculosis and lung diseases

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