Fine needle aspiration cytology of neuroendocrine carcinoma of the breast--a case report and review of literature.

Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
The Malaysian journal of pathology 07/2008; 30(1):57-61.
Source: PubMed

ABSTRACT Neuroendocrine carcinomas of the breast are uncommon tumors known to occur in the elderly. While focal neuroendocrine differentiation may be noted in many ductal and lobular carcinomas, the term neuroendocrine carcinoma is to be applied when more than 50% of the tumor shows such differentiation. This case report details the cytological features of a neuroendocrine carcinoma that was encountered in our hospital. The fine needle aspiration (FNA) smears showed discohesive polygonal cells with abundant cytoplasm, many of which contained eosinophilic granules located at one pole. Histology of the mastectomy and axillary lymph nodes specimen from this patient showed features of neuroendocrine carcinoma--solid type, with metastasis, confirmed with immunohistochemistry. The patient is disease free seven months after surgery. This case highlights the need to closely observe cytological details to identify this rare tumor that may otherwise appear to be invasive duct carcinoma--not otherwise specified on FNA. The implications of diagnosing neuroendocrine differentiation for prognosis and management are also discussed.

  • [Show abstract] [Hide abstract]
    ABSTRACT: A 13-year-old female neutered Boxer dog was presented with a history of chronic intermittent haemorrhagic diarrhoea. Cytological evaluation of fine-needle aspirate samples from an enlarged mesenteric lymph node revealed an individualised round to polygonal cell population with poorly defined cell margins and marked anisocytosis and anisokaryosis. The nuclei were round to oval with lacey chromatin and commonly nucleoli. The cytoplasm was lightly basophilic and rarely contained variable numbers of fine red to purple granules. The cytological interpretation was anaplastic neoplasia, most likely a poorly differentiated, high-grade mast-cell neoplasm. Histologic evaluation of the lymph node and a liver nodule revealed densely cellular, solid sheets and nests of pleomorphic round to polygonal neoplastic cells separated by a fine fibrovascular stroma. The cells had granular cytoplasm with no evidence of metachromatic staining using toluidine blue and Giemsa stains. Immunohistochemically, the neoplastic cells were positive for chromogranin A, neuron-specific enolase and synaptophysin, and negative for cytokeratin AE1/AE3 and S-100. A final diagnosis of neuroendocrine carcinoma was made.
    Comparative Clinical Pathology 01/2012; 19(4).
  • [Show abstract] [Hide abstract]
    ABSTRACT: Objetivo: Presentar un caso de carcinoma en tejido mamario ectópico axilar. Presentación del caso: Paciente femenina de 38 años de edad, quien consultó por aumento de volumen y nódulo en región axilar de un año de evolución y punción aspiración por aguja fina previa no diagnóstica. En la evaluación se observó mamas axilares bilaterales, palpando en la derecha tumor duro de superficie irregular, se realizó mamografía, C y biopsia por aguja gruesa. Por el diagnóstico de la biopsia por aguja gruesa, se practicaron estudios de extensión y se trató con neoadyuvancia y cirugía. El estudio histopatológico de la pieza quirúrgica concluyó carcinoma ductal infiltrante con patrón neuroendocrino y metástasis en 2 de 18 ganglios, recibió adyuvancia y se mantiene libre de enfermedad.
    Revista de obstetricia y ginecología de Venezuela 12/2012; 72(4):277-279.

Full-text (2 Sources)

Available from
May 16, 2014