Hepatitis C virus and Human Immunodeficiency Virus coinfection among attendants of Voluntary Counseling and Testing Centre and HIV follow up clinics in Mekelle Hospital.
ABSTRACT Hepatitis C virus remains a large health care burden to the world. HIV and HCV coinfection is major global health concern worldwide. However, there is limited information on the prevalence of HCV/HIV co-infection in Ethiopia. The aim of the study was to assess the magnitude of HIV/HCV coinfection and the potential risk factors in attendants of voluntary counseling and testing centre and HIV follow up clinics of Mekelle hospital.
A cross sectional seroprevalence survey of HCV infection was carried out on 300 HIV negative and positive subjects attending voluntary counseling and testing (VCT) center and HIV follow up clinics of Mekelle hospital, Ethiopia from December 2010-February 2011. Serum samples were tested for anti-HCV antibodies using immunochromatographic test.
Of the 300 study participants, 126(42%) were HIV negative and 174(58%) HIV seropositive from VCT and HIV follow up clinics, respectively. The overall anti-HCV prevalence was 18(6.0%). There were no significant differences in HCV seroprevalence among the different categories of age and sex (p> 0.05). Of the 174 persons with HIV, 16 (9.2%) cases had antibodies to HCV, where as among 126 HIV negative subjects 2 (1.58%) were HCV seropositive (p= 0.006, OR= 6.28, 95% CI= 1.42-27.82).
Accordingly, there was a significant difference in sero-positivity of HCV between HIV positive and HIV negative participants. No apparent risk factor that caused HCV infection was inferred from this study.
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ABSTRACT: Abstract Background Liver hepatitis due to Hepatitis B (HBV) and hepatitis C virus (HCV) co-infection is the leading cause of morbidity and mortality in HIV infected children and it is more severe in resource poor settings. Data on seroprevalence of HBV and HCV among HIV infected children are scarce in Ethiopia. This study was conducted to determine seroprevalence and risk factors of HBV and HCV and its effect on liver enzyme among HIV-positive children aged 18?months to 15?years attending the paediatric HIV care and treatment clinic at Felege Hiwot referral hospital, Ethiopia. Methods A cross-sectional study was conducted in May, 2014. Demographic and risk factors were collected using a structured questionnaire. Hepatitis B surface antigen (HBsAg) and anti-HCV antibodies were detected using an enzyme linked immunosorbent assay (ELISA). Alanine aminotransferase (ALT) levels were determined. The results were analyzed using descriptive and logistic regression. Results A total of 253 HIV positive children, boys (52.5%) and girls (47.5%) took part in the study. The median age of the children was 11?years. Overall, 19 (7.5%) of HIV infected children were positive either for HBsAg or anti-HCV antibodies. The seroprevalence of HBV and HCV were 2.0% and 5.5%, respectively. All HBsAg positive children were in older age groups (11-15years). Seroprevalence of HCV was higher in children from urban (7.7%) than rural (1.2%) residents (P?=?0.02). Overall, 29 (12.1%) of children had elevated ALT. Of these, 31.5% were from HBsAg or anti-HCV antibody positive children whereas 9.8% were from hepatitis B or C virus negative children (P?=?0.001). Multivariate logistic regression showed that being positive for HBsAg or anti-HCV antibody (AOR: 4.7(95% CI: 1.5-13.5) was significantly associated with elevated ALT. Conclusion HBV and HCV co-infections are common in HIV positive children. In HIV positive children, HBV and HCV co-infection were associated with elevate ALT. Routine screening for HBV and HCV in HIV infected children should be implemented.BMC Research Notes 11/2014; 7(1):838. DOI:10.1186/1756-0500-7-838
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ABSTRACT: Introduction La prévalence du virus de l’hépatite C (VHC) n’est pas bien connue au Burundi. Des études parcellaires rapportent des taux variés. Aucune étude couvrant le territoire national n’avait été faite. But Déterminer la prévalence des anticorps anti virus de l’hépatite C (AcVHC) au Burundi. Méthodes Lors d’une enquête nationale de séroprévalence du VIH menée par le CEFORMI du CHU Kamenge en 2002, entre 2 et 4 ml de sérum et de plasma ont été décantés pour chaque échantillon puis conservés à -20°C pour usage ultérieur. Nous avons repris et analysé ces échantillons. Résultats Au total, 5569 individus ont été enrôlées, 2660 (47,8%) hommes et 2909 (52,2%) femmes. L’âge moyen était de 31±15 ans avec une médiane de 28 ans. Au niveau national, la prévalence globale des AcVHC était de 8,2%. Elle était de 8,3% chez l’homme et de 8,1% chez la femme. Selon les strates, la prévalence était de 10% en zone urbaine, de 9,1% en zone semi-urbaine et de 7,4% en zone rural. La co-infection avec le VIH était de 1,3% en zone urbaine, de 0,8% en zone semi-urbaine et de 0,1% en zone rurale. Conclusion La prévalence du virus de l’hépatite C est estimée à 8,2%. Elle est parmi les plus élevées en Afrique.Journal Africain d?Hépato-Gastroentérologie 03/2014; 8(1):25-28. DOI:10.1007/s12157-014-0511-6
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ABSTRACT: Human immunodeficiency virus (HIV), Hepatitis B (HBV) and Hepatitis C (HCV) are blood-borne viruses with potentially shared routes of transmission. In high-income settings, the impact of antiretroviral therapy (ART) on survival has unmasked chronic liver disease from viral hepatitis B or hepatitis C as a leading cause of morbidity and mortality in individuals with HIV infection. It is now feared that progressive liver disease may threaten the success of ART programmes in developing countries, where HCV or HBV testing and monitoring are not yet systematic among HIV-infected patients and ART use is generally blind to these co-infections. We set out to review recent data from Sub-Saharan Africa, in order to build a detailed and up-to-date picture of the epidemiology and emerging impact of HBV and HCV coinfection in countries at the heart of the HIV pandemic. There is a preponderance of HIV/HBV coinfection compared to HIV/HCV in this region, and significant caveats exist regarding the accuracy of published HCV seroprevalence surveys. Morbidity and mortality of coinfection is significant, and may be further enhanced in African populations due to the influence of host, viral and environmental factors. Careful scrutiny of the coinfection problem is vital to inform an approach to directing resources, planning public health initiatives, providing clinical care, and guiding future research.Journal of Clinical Virology 09/2014; 61(1). DOI:10.1016/j.jcv.2014.05.018 · 3.47 Impact Factor