A Reactive Oxygen Species (ROS)-Responsive Polymer for Safe, Efficient, and Targeted Gene Delivery in Cancer Cells.

The Wallace H. Coulter Department of Biomedical Engineering, School of Chemistry & Biochemistry and School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332 (USA)
Angewandte Chemie International Edition (Impact Factor: 11.34). 05/2013; DOI: 10.1002/anie.201209633
Source: PubMed

ABSTRACT Stimuli-responsive release: The high levels of reactive oxygen species (ROS) in prostate cancer cells can be exploited to trigger cancer-targeted gene delivery. A ROS-responsive thioketal-based cationic polymer was synthesized and functionalization with a cancer-targeting peptide led to selective and enhanced gene transfection in prostate cancer cells.

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