Article

Immunomodulatory effects of Abnormal Savda Munsiq, a traditional Uighur medicine, on the combined stress mice.

Traditional Uighur Medicine Department, Xinjiang Medical University, 8 Medical University Road, Urumqi 830054, Xinjiang, China.
Journal of ethnopharmacology (impact factor: 2.32). 01/2009; 122(1):42-7. DOI:10.1016/j.jep.2008.11.023
Source: PubMed

ABSTRACT To investigate the immunomodulatory effects of ASMq, a herbal preparation used in Traditional Uighur Medicine, on the combined stress mice.
The combined stress was induced on mice by application of the electric-foot shock in a cold-dry environment and three different doses of ASMq were orally administered to the animals for 14 days. The effect of ASMq on the immune apparatus weight index, lymphocytes proliferation, serum levels of the cytokines, immunoglobulins, hemolysin and NK cells as well as the phagocytic activity of the macrophages were evaluated.
Oral administration of ASMq was found to increase the thymus and spleen indices, lymphocytes proliferation induced by Con A and LPS, the percentage of CD4(+) in thymus, spleen and peripheral blood and restore the CD4(+)/CD8(+) ratio. The serum concentrations of INF-beta, IL-2, IL-6, IgG, NK cells and hemolysin were also increased. The macrophage phagocytic activity was also enhanced.

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Keywords

cold-dry environment
 
combined stress
 
combined stress mice
 
electric-foot shock
 
IL-2
 
IL-6
 
immune apparatus weight index
 
immunomodulatory effects
 
INF-beta
 
LPS
 
macrophage phagocytic activity
 
mice
 
NK cells
 
Oral administration
 
peripheral blood
 
phagocytic activity
 
serum concentrations
 
serum levels
 
spleen indices
 
Traditional Uighur Medicine