Article

Combined cardiac sympathetic excitation and vagal impairment in patients with non-organic erectile dysfunction.

Department of Urology, Hualien General Hospital, Department of Health, Executive Yuan, Taiwan.
Clinical neurophysiology: official journal of the International Federation of Clinical Neurophysiology (Impact Factor: 2.98). 02/2009; 120(2):348-52. DOI: 10.1016/j.clinph.2008.10.155
Source: PubMed

ABSTRACT Patients with non-organic erectile dysfunction (ED) frequently present with syndromes involving systemic sympathovagal dysfunction. The linkage of ED to cardiac autonomic regulation is not well understood.
Forty-four men with non-organic ED and 38 healthy age-matched control subjects with ages ranging from 40 years to 69 years were recruited. These two groups were divided into three distinct age categories at 10-year intervals. Patients were divided into three different severity categories, among whom 35 patients received a two-month oral treatment of trazodone. Power spectral analysis of successive R-R intervals (RR) was performed to evaluate the variance (variance of RR-interval values), the high-frequency power (HF), and the ratio of low-frequency power to HF (LF/HF) of their heart rate variability (HRV).
Patients exhibited a significantly lower variance and HF, but a higher LF/HF compared to the control group across all age categories. The changes in variance and HF were severity dependent. In addition, all the HRV parameters of the patients with a satisfactory response after treatment have significantly improved.
The results indicate that patients with non-organic ED had significant cardiac sympathetic hyperactivity and severity-dependent cardiac vagal impairment.
Non-organic ED may be accompanied by an abnormality in cardiac autonomic regulation.

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