In recent years, circannual variations in incidence and mortality for venous thromboembolic disease have been demonstrated, with a peak in winter. However, several investigators have observed no seasonal variation in these diseases. The aim of our study was to investigate whether a seasonal variation, in terms of atmospheric pressure, humidity, and temperature, exists for pulmonary thromboembolism.
We retrospectively included 206 patients with a diagnosis of pulmonary embolism (PE) between 1 June 2001 and 31 May 2006.
The highest number of cases in the 5 years concerned occurred in May (29 cases). Although PE occurred most commonly in the spring (72 cases) and autumn (51 cases), the difference was statistically significant (P = .003). There were no case correlations with months and pressure, temperature, or humidity. However, there was a statistically significant positive correlation between case incidence and atmospheric pressure (r = 0.53, P < .0005) and humidity (r = 0.57, P < .0005). In terms of risk factors, seasonal distribution was not statistically significant as regards cases of embolism occurring for surgical or nonsurgical reasons (r = 0.588).
In terms of the relationship between seasons and embolism cases, despite the determination of an insignificant positive correlation, a statistically significant positive correlation was determined between air pressure and humidity and case incidence. There is now a need for further wide-ranging prospective studies including various hematological parameters to clarify the correlation between PE and air pressure.
[Show abstract][Hide abstract] ABSTRACT: Seasonal variations in the incidence of cardiovascular disease, mainly characterized by a winter peak, have been consistently reported. Some evidence now also exists on potential seasonal variations in the incidence of venous thromboembolism (VTE). Of interest, seasonal variability in the incidence of deep vein thrombosis and fatal and nonfatal pulmonary embolism appears to differ; however, the results of available studies are not unequivocal. This review will briefly summarize current evidence in this area.
Recent studies indicate a seasonal variability in the incidence of VTE, with a pattern that is independent of sex, age, type of event, or underlying risk factors. Usually, these studies found a higher VTE incidence during the winter months and a lower incidence in the summer months. The exact mechanism of this variability is not completely understood, but it may be at least in part explained by changes in coagulation factor levels.
Confirmation of these findings and a better understanding of underlying mechanisms could help physicians to identify patients or periods with increased risk of VTE in order to further improve current prophylactic strategies.
Current opinion in pulmonary medicine 07/2009; 15(5):403-7. DOI:10.1097/MCP.0b013e32832d867a · 2.76 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Rhythmic patterns have been observed in most biological functions, and oscillations with a peak and trough have been demonstrated for many bodily functions, including arterial blood pressure, heart rate, vascular tone, coagulation, and fibrinolysis. Depending on cycle length, these oscillations can be circadian, ultradian, circannual, or seasonal. In recent decades, many studies have investigated the possibility of seasonal variations in several diseases, especially in the cardiovascular system and specifically in some arterial and venous diseases. Traditionally, the two vascular beds have been considered as separate entities, each characterized by its own risk factors and diseases. Recently, however, a series of findings has revealed analogs between these two entities that are also supported by chronobiological findings. The latest findings about seasonal variations in major arterial and venous diseases and possible common underlying risk factors are presented and discussed here.
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