"Levin et al.  showed that QHPV was safe, immunogenic and did not alter CD4+ % or plasma HIV-RNA in a cohort of HIV-infected children and adolescents aged 7–12 years. Results from a multicenter trial performed by the Adolescent Medicine Trials Network for HIV/AIDS Interventions, in young women aged 16–23 years (n = 99), indicated that immune responses to QHPV were robust and the vaccine well tolerated . "
[Show abstract][Hide abstract] ABSTRACT: The ability of a quadrivalent human papilloma virus (HPV)-16/18/6/11 VLP vaccine (Gardasil) to elicit HPV-specific cell-mediated immune responses was evaluated in antiretroviral therapy (ART)-treated HIV-infected young adults. Results showed that, after three doses of vaccine, central memory and effector memory CD4+ and CD8+ T lymphocytes, as well as HPV-specific interleukin (IL)2+/CD4+, interferon-gamma (IFN-[gamma]+)/CD4+, IFN-[gamma]+/CD8+ and tumour necrosis factor-alpha (TNF-[alpha])+/CD8+ T lymphocytes and Perforin and Granzyme B secreting CD8+ T lymphocytes were significantly increased. Notably, results obtained in HIV-infected patients were comparable to those seen in HIV-uninfected age-matched healthy controls.
AIDS 03/2015; 29(6). DOI:10.1097/QAD.0000000000000597 · 5.55 Impact Factor
"Quadrivalent HPV vaccine was immunogenic and well tolerated in HIV-infected young women in a recent study (29). HPV vaccine is recommended by the Advisory Committee on Immunization Practices (ACIP) for HIV-infected individuals through age 26 yr for those who did not get any or all doses when they were younger (30). "
[Show abstract][Hide abstract] ABSTRACT: The epidemiology on human papillomavirus (HPV) among human immunodeficiency virus (HIV)-infected women in Korea is not well established. A retrospective study was conducted to determine the prevalence and genotype distribution of HPV infection among HIV-infected women in Korea. HPV DNA genotype and cervical cytology were examined in 60 HIV-positive women and 1,938 HIV-negative women. HPV genotypes were analyzed by using a HPV DNA chip. HIV-infected women had higher prevalence of high-risk HPV (hr-HPV) infection (30% vs 4.9%, adjusted odds ratio [AOR], 6.96; 95% confidence interval [CI], 3.63-13.34, P<0.001) and abnormal cervical cytology (18.3% vs 1.8%, AOR, 10.94; 95% CI, 5.18-23.1, P<0.001) compared with controls. The most common hr-HPV genotype detected in HIV-infected women was HPV 16 (10%), followed by 18 (6.7%) and 52 (5%). Prevalence of quadrivalent vaccine-preventable types (HPV 6, 11, 16, and 18) was 21.7% and 2.3% in HIV-positive women and HIV-negative women, respectively. Age was a significant risk factor for hr-HPV infection in HIV-infected women (P=0.039). The presence of hr-HPV was significantly associated with abnormal cervical cytology (P<0.001). These findings suggest that HPV testing for cervical cancer screening in HIV-infected women would be necessary, particularly among young age group.
Journal of Korean medical science 01/2014; 29(1):32-7. DOI:10.3346/jkms.2014.29.1.32 · 1.27 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Background:
We compared the immunogenicity and reactogenicity of Cervarix or Gardasil human papillomavirus (HPV) vaccines in adults infected with the human immunodeficiency virus (HIV).
This was a double-blind, controlled trial randomizing HIV-positive adults to receive 3 doses of Cervarix or Gardasil at 0, 1.5, and 6 months. Immunogenicity was evaluated for up to 12 months. Neutralizing anti-HPV-16/18 antibodies were measured by pseudovirion-based neutralization assay. Laboratory tests and diary cards were used for safety assessment. The HPV-DNA status of the participants was determined before and after immunization.
Ninety-two participants were included in the study. Anti-HPV-18 antibody titers were higher in the Cervarix group compared with the Gardasil group at 7 and 12 months. No significant differences in anti-HPV-16 antibody titers were found among vaccine groups. Among Cervarix vaccinees, women had higher anti-HPV-16/18 antibody titers compared to men. No sex-specific differences in antibody titers were found in the Gardasil group. Mild injection site reactions were more common in the Cervarix group than in the Gardasil group (91.1% vs 69.6%; P = .02). No serious adverse events occurred.
Both vaccines were immunogenic and well tolerated. Compared with Gardasil, Cervarix induced superior vaccine responses among HIV-infected women, whereas in HIV-infected men the difference in immunogenicity was less pronounced.
The Journal of Infectious Diseases 11/2013; 209(8). DOI:10.1093/infdis/jit657 · 6.00 Impact Factor
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