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Microarrays and microneedle arrays for delivery of peptides, proteins, vaccines and other applications

Purdue University, Department of Industrial and Physical Pharmacy , West Lafayette, IN 47907 , USA.
Expert Opinion on Drug Delivery (Impact Factor: 4.12). 05/2013; 10(8). DOI: 10.1517/17425247.2013.797405
Source: PubMed

ABSTRACT Introduction: Peptide and protein microarray and microneedle array technology provides direct information on protein function and potential drug targets in drug discovery and delivery. Because of this unique ability, these arrays are well suited for protein profiling, drug target identification/validation and studies of protein interaction, biochemical activity, immune responses, clinical prognosis and diagnosis and for gene, protein and drug delivery. Areas covered: The aim of this review is to describe and summarize past and recent developments of microarrays in their construction, characterization and production and applications of microneedles in drug delivery. The scope and limitations of various technologies in this respect are discussed. Expert opinion: This article offers a review of microarray/microneedle technologies and possible future directions in targeting and in the delivery of pharmacologically active compounds for unmet needs in biopharmaceutical research. A better understanding of the production and use of microarrays and microneedles for delivery of peptides, proteins and vaccines is needed.

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    • "In addition to DNA microarrays, protein chips are also utilized in drug discovery (Chandrasekhar et al. 2013). The feasibility of using protein microarray in HTS was established at the beginning of this century (MacBeath and Schreiber 2000; Zhu et al. 2000). "
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    • "Microneedle (MN) devices are composed of an array of micronsize needles. These systems are currently attracting great interest in transdermal drug delivery research (Chandrasekhar et al., 2013; Henry et al., 1998; Kim et al., 2012; Tuan-Mahmood et al., 2013). MN has the ability to pierce the outermost layer of the skin, the stratum corneum (SC) and create micro-conduits that can deliver drugs to the deeper layers of the skin from where they can be absorbed directly into the systemic circulation (Prausnitz, 2004). "
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