The evolution of drug-resistant malaria.

Howard Hughes Medical Institute, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Transactions of the Royal Society of Tropical Medicine and Hygiene (Impact Factor: 1.93). 04/2009; 103 Suppl 1:S11-4. DOI: 10.1016/j.trstmh.2008.11.002
Source: PubMed

ABSTRACT Molecular epidemiological investigations have uncovered the patterns of emergence and global spread of Plasmodium falciparum resistance to chloroquine and sulfadoxine-pyrimethamine. Malaria parasites highly resistant to chloroquine and pyrimethamine spread from Asian origins to Africa, at great cost to human health and life. If artemisinin-resistant falciparum malaria follows the same pattern, renewed efforts to eliminate and eradicate malaria will be gravely threatened. This paper, adapted from a talk given in honour of Professor Malcolm Molyneux in Liverpool in September 2008, reviews the rise and fall of clinically important forms of drug-resistant falciparum malaria and considers how lessons learned from studying the evolution of drug-resistant malaria can be applied to efforts to prevent and deter resistance.

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Available from: Christopher V Plowe, Jul 01, 2015
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