Article

Synthesis and rheological properties of hydrogels based on amphiphilic alginate-amide derivatives.

Laboratoire de Chimie Physique Macromoléculaire, UMR 7568 CNRS-Université de Nancy1, rue Grandville, B.P. 20451, F-54001 Nancy, France.
Carbohydrate research (impact factor: 2.03). 12/2008; 344(2):223-8. DOI:10.1016/j.carres.2008.10.029 pp.223-8
Source: PubMed

ABSTRACT New amphiphilic derivatives of sodium alginate were prepared by covalent attachment of dodecylamine onto the polysaccharide via amide linkages at different substitution ratios, using 2-chloro-1-methylpyridinium iodide (CMPI) as coupling reagent. The aim was to limit the progressive loss of associative behaviour which occurs in the case of previously described dodecyl ester alginate derivatives due to hydrolysis of ester bonds. A series of hydrogels was obtained which differed by the amount of attached dodecyl tails. The stability and viscoelastic properties were evaluated and compared to those of hydrogels obtained with alginate esters. The observed differences were discussed in relation to the synthesis procedures. The advantages of amide links are underlined, especially with regard to long-term stability of hydrogels.

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Keywords

2-chloro-1-methylpyridinium iodide
 
amide linkages
 
amide links
 
associative behaviour
 
CMPI
 
different substitution ratios
 
dodecyl tails
 
dodecylamine
 
hydrogels
 
New amphiphilic derivatives
 
observed differences
 
sodium alginate
 
viscoelastic properties