Relevance of Magnetic Resonance Imaging for Early Detection and Diagnosis of Alzheimer Disease

University Medicine Rostock, Rostock, Germany
The Medical clinics of North America (Impact Factor: 2.8). 05/2013; 97(3):399-424. DOI: 10.1016/j.mcna.2012.12.013
Source: PubMed

ABSTRACT Magnetic resonance imaging (MRI)-based indicators of regional and global brain atrophy and more advanced measures of cortical functional and structural connectivity are among the most promising imaging biomarkers for the characterization of preclinical and prodromal stages of Alzheimer disease (AD). This review presents the current status of available and evolving MRI-based technologies for the early asymptomatic and predementia diagnosis of AD, including high-resolution structural MRI of global and regional brain atrophy, diffusion tensor imaging of structural cortical connectivity, and functional MRI during rest and task performance. The selection of an appropriate technique needs to consider its suitability for specific applications.

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Available from: Michel Grothe, May 13, 2014
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    • "The deposition of neurofibrillary tangles begins primarily in the limbic system structures, initially in the entorhinal cortex and the medial temporal regions, then progressively spread across the cerebral cortex. Hippocampal and entorhinal cortical atrophy assessed with MRI is well documented in patients with AD (Teipel et al., 2013), and in many with MCI (Pihlajamaki et al., 2009). Furthermore, this observation has extended the investigation of all limbic structures in relation to disease progression and cognitive performance. "
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    Frontiers in Aging Neuroscience 01/2015; DOI:10.3389/fnagi.2014.00343 · 2.84 Impact Factor
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    • "67 [42–85] 78 [60–92] ++++ 79 [64–91] ++++ MMSE: mean (range) 27 [6–30] 25 [16] [17] [18] [19] [20] [21] [22] [23] [24] [25] [26] [27] [28] [29] [30] 21 [13–29] Clock drawing test mean (range) 6 [0] [1] [2] [3] [4] [5] [6] [7] 5 [2] [3] [4] [5] [6] [7] 4 [0] [1] [2] [3] [4] [5] [6] [7] GMV [ml] "
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    Journal of Alzheimer's disease: JAD 09/2014; 44(1). DOI:10.3233/JAD-141446 · 4.15 Impact Factor
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    • "Interestingly, the cerebellum is a common area that can be thought as a node of several RSNs including the DMN. Although previous works have suggested a cerebellar involvement in AD and MCI (Wang et al., 2007; Kaufmann et al., 2008; Thomann et al., 2008; Bai et al., 2009, 2011b; Solé-Padullés et al., 2009; Teipel et al., 2013), the alteration in FC in the cerebellum in AD and MCI remains unclear. "
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