Efficacy of sodium hypochlorite and chlorhexidine against Enterococcus faecalis - A systematic review

Federal University of Goiás, Goiânia, GO, Brazil.
Journal of applied oral science: revista FOB (Impact Factor: 0.8). 11/2008; 16(6):364-8. DOI: 10.1590/S1678-77572008000600002
Source: PubMed

ABSTRACT The efficacy of the sodium hypochlorite (NaOCl) and chlorhexidine (CHX) on Enterococcus faecalis was evaluated by systematic review and meta-analysis. The search strategies included search in electronic biomedical journal databases (MEDLINE, EMBASE, CENTRAL) and handsearching records, using different matches of keywords for NaOCl, CHX and Enterococcus faecalis. From 41 in vivo studies, 5 studies met the inclusion criteria. In a sample containing 159 teeth, E. faecalis was detected initially in 16 (10%) teeth by polymerase chain reaction (PCR) and 42 (26.4%) teeth by microbial culture techniques. After root canal disinfection, this species was observed in 11 (6.9%) teeth by PCR and 12 (7.5%) teeth by culture. Risk differences of included studies were combined as generic inverse variance data type (Review Manager Version 5.0 _ Cochrane Collaboration,, accessed 15 May 2008), taking into account the separate tracking of positive and negative cultures/PCR. The level of statistical significance was set at p<0.05. In conclusion, NaOCl or CHX showed low ability to eliminate E. faecalis when evaluated by either PCR or culture techniques.

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Available from: Cláudio Rodrigues Leles, Feb 18, 2014
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    • "Most of the chemical substances show adverse factors, such as toxicity, non-physiological pH, unpleasant odor and taste, and inability to degrade organic matter and smear layer. One of the most widely indicated substance is SH diluted to 1% (Estrela et al., 2008). The use of SH as irrigation solution is part of the protocols established to prepare root canals to endodontic treatments, considering that removal of any microorganism is fundamental to avoid any further relapse. "
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    Brazilian Journal of Microbiology 10/2014; 45(3):769-79. DOI:10.1590/S1517-83822014000300002 · 0.45 Impact Factor
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    • "In dental root canal, eradication of E. faecalis with chemomechanical preparations and using antiseptics is difficult [11] . Even the most used antiseptics in endodontic treatments, sodium hypochlorite and chlorhexidine showed low ability to eliminate E. faecalis [16] . "
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    ABSTRACT: To evaluate some essential oils in treatment of intractable oral infections, principally caused by biofilm of multidrug-resistant Enterococcus faecalis (E. faecalis), such as persistent endodontic infections in which their treatment exhibits a real challenge for dentists.
    Asian Pacific Journal of Tropical Biomedicine 06/2014; 4(6):463-72. DOI:10.12980/APJTB.4.2014C1203
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