Finding the nerve: diabetic neuropathy often goes undercover, but doctors have ways to unmask it
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ABSTRACT: Autonomic dysfunction (AD) accompanying with chronic liver disorders led to an increased risk of mortality. However, researches that investigated the association between nonalcoholic fatty liver disease (NAFLD) and AD were insufficient. To study the association of NAFLD with AD in middle-aged and elderly Chinese adults. Design: 4974 adults aged 40 years or older were enrolled in this cross-sectional study. NAFLD was diagnosed by hepatic B-mode ultrasonography. Autonomic function was assessed using a simple EZSCAN® test by measuring sudomotor function, with an AD index > 50% defined as a manifestation of AD. Pearson correlation, multiple stepwise linear regression, univariate and multivariate logistic regression was employed to examine the relationship between NAFLD and AD, controlling for potential confounders. The prevalence of AD was significantly higher in participants with NAFLD than those without (40.75% vs. 26.86%, p < 0.0001). Age, body mass index (BMI), status of diabetes, sex, diastolic blood pressure (DBP) and prevalent NAFLD, were positively correlated with AD index in multiple stepwise linear regression analysis (all p < 0.05), whereas total cholesterol was negatively related to it (p = 0.0043). Compared with the participants without NAFLD, those with NAFLD had an increased odds of the prevalent AD (odds ratio 1.38; 95% confidence interval [CI] 1.15-1.64; p = 0.0004) after controlling for multiple confounders. The presence of NAFLD was significantly associated with AD, as indicated by abnormal sudomotor function. The association was independent from various conventional risk factors. © The Author 2015. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For Permissions, please email: email@example.com.QJM: monthly journal of the Association of Physicians 01/2015; 108(8). DOI:10.1093/qjmed/hcv006 · 2.50 Impact Factor
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