Buruli ulcer: reductive evolution enhances pathogenicity of Mycobacterium ulcerans.
ABSTRACT Buruli ulcer is an emerging human disease caused by infection with a slow-growing pathogen, Mycobacterium ulcerans, that produces mycolactone, a cytotoxin with immunomodulatory properties. The disease is associated with wetlands in certain tropical countries, and evidence for a role of insects in transmission of this pathogen is growing. Comparative genomic analysis has revealed that M. ulcerans arose from Mycobacterium marinum, a ubiquitous fast-growing aquatic species, by horizontal transfer of a virulence plasmid that carries a cluster of genes for mycolactone production, followed by reductive evolution. Here, the ecology, microbiology, evolutionary genomics and immunopathology of Buruli ulcer are reviewed.
- SourceAvailable from: Santanu Dasgupta
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- "Mycobacterium tuberculosis, Mycobacterium leprae and Mycobacterium ulcerans, the etiological agents of tuberculosis (TB; 10 million new cases per year develop active disease), leprosy and Buruli ulcer (the third most common mycobacterium infection), respectively (see e.g. Sasaki et al. 2001; Russell 2007; Demangel et al. 2009). While M. tuberculosis is human-specific, the closely related Mycobacterium bovis can infect both humans and animals and lead to TB regardless of host. "
ABSTRACT: Bacteria have the ability to adapt to different growth conditions and to survive in various environments. They have also the capacity to enter into dormant states and some bacteria form spores when exposed to stresses such as starvation and oxygen deprivation. Sporulation has been demonstrated in a number of different bacteria but Mycobacterium spp. have been considered to be non-sporulating bacteria. We recently provided evidence that Mycobacterium marinum and likely also Mycobacterium bovis bacillus Calmette-Guérin can form spores. Mycobacterial spores were detected in old cultures and our findings suggest that sporulation might be an adaptation of lifestyle for mycobacteria under stress. Here we will discuss our current understanding of growth, cell division, and sporulation in mycobacteria.Antonie van Leeuwenhoek 05/2010; 98(2):165-77. DOI:10.1007/s10482-010-9446-0 · 2.14 Impact Factor
Conference Paper: Vietnam's strategy of technology development: some managerial issues[Show abstract] [Hide abstract]
ABSTRACT: Major trends in science and technology policy reform in Vietnam have been reviewed in this paper. Based upon this analysis, some suggestions have been made to improve endogenous capacity through policy options relating to technology planning with participation, technology evaluation, utilization of local experts, promotion of rural areas, and development of technology services and environmental integrationManagement of Engineering and Technology, 1999. Technology and Innovation Management. PICMET '99. Portland International Conference on; 02/1999
Conference Paper: Technology status and opportunities of VCSELs[Show abstract] [Hide abstract]
ABSTRACT: Central to the photonic revolution is the development of miniature light sources such as the vertical-cavity surface-emitting laser (VCSEL). Today, VCSEL manufacturing has been established to serve data and telecommunication applications. Moreover, recent progress in new materials, fabrication technologies, and microcavity physics has enabled a new generation of high performance VCSELs. We will overview the present and near-term commercial VCSELs as well as discuss recent research, including new device structures such as 2-dimensional VCSEL arrays, composite resonators, and photonic crystal devices.Indium Phosphide and Related Materials Conference, 2002. IPRM. 14th; 02/2002