Article

Mobilization of qnrB2 and ISCR1 in plasmids.

Division of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, Taiwan.
Antimicrobial Agents and Chemotherapy (Impact Factor: 4.45). 01/2009; 53(3):1235-7. DOI: 10.1128/AAC.00970-08
Source: PubMed

ABSTRACT The DNA sequences of two IncHI2 plasmids, pEC-IMP and pEC-IMPQ, from metallo-beta-lactamase-producing Enterobacter cloacae clinical isolates were determined. The two conjugative plasmids are almost identical, but pEC-IMPQ carries an additional segment containing an orf513 (ISCR1), a truncated 3' conserved sequence, and a qnrB2. Comparative analyses provide support for the proposed ISCR1-mediated gene mobilization.

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