Article

Mobilization of qnrB2 and ISCR1 in plasmids.

Division of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, Taiwan.
Antimicrobial Agents and Chemotherapy (impact factor: 4.84). 01/2009; 53(3):1235-7. DOI:10.1128/AAC.00970-08 pp.1235-7
Source: PubMed

ABSTRACT The DNA sequences of two IncHI2 plasmids, pEC-IMP and pEC-IMPQ, from metallo-beta-lactamase-producing Enterobacter cloacae clinical isolates were determined. The two conjugative plasmids are almost identical, but pEC-IMPQ carries an additional segment containing an orf513 (ISCR1), a truncated 3' conserved sequence, and a qnrB2. Comparative analyses provide support for the proposed ISCR1-mediated gene mobilization.

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Keywords

additional segment
 
Comparative analyses
 
DNA sequences
 
metallo-beta-lactamase-producing Enterobacter cloacae clinical
 
pEC-IMP
 
pEC-IMPQ
 
proposed ISCR1-mediated gene mobilization
 
truncated 3' conserved sequence