A novel amperometric sensor for the detection of difenidol hydrochloride based on the modification of Ru(bpy)(3)(2+) on a glassy carbon electrode.
ABSTRACT An amperometric sensor for the detection of difenidol, a tertiary amine-containing analyte, was proposed. Ruthenium(II) tris(bipyridine)/multi-walled carbon nanotubes/Nafion composite film was suggested to modify the glassy carbon electrode. The modified electrode was shown to be an excellent amperometric sensor for the detection of difenidol hydrochloride. The linear range is from 1.0x10(-6) to 3.3x10(-5)M with a correlation coefficient of 0.998. The limit of detection was 5x10(-7)M, which was obtained through experimental determination based on a signal-to-noise ratio of three. The sensor was employed to the determination of the active ingredients in the tablets containing difenidol hydrochloride.
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ABSTRACT: Microfluidic lab-on-a-chip allows chemical and biochemical analysis to be conducted in a miniaturized system. Miniaturized analysis reduces the reagent consumption while decreasing the overall size of the device, but the small dose of the sample make detection more demanding and is more sensitive to adsorption of species on the surface. Integration of carbon nanotubes into microfludic devices is a promising approach. This review addresses recent advances in the application of carbon nanotubes for microfluidic lab-on-a-chip. The literature review shows that carbon nanotubes have been used to achieve superlubrifying microchannels, act as high density nanoporous membranes, electrical transducers mainly in flow sensors and biosensors, and mimics of living systems. In addition, extensive work has been carried out to investigate the tunable mechanical, chemical and electrical properties of carbon nanotubes in order to manipulate and analyse extremely small volumes of fluid effectively.International Journal of Material Forming 06/2008; 1(2):117-125.
Article: Phenanthroline derivatives electrochemically grafted to glassy carbon for Cu(II) ion detection[show abstract] [hide abstract]
ABSTRACT: a b s t r a c t New sensing platform based on modified glassy carbon (GC) suitable for design of heavy metal-ion sensor is reported in this study. GC-based electrodes were electrochemically modified by poly-5-nitro-1,10-phenanthroline (poly-5NP) and poly-5-amino, 6-nitro-1,10-phenanthroline (poly-5A6NP) layers. Grafting of electrochemically formed poly-5NP and poly-5A6NP layers at the GC electrode surface was confirmed by electrochemical reduction of nitro groups into amine groups. Presence of grafted poly-5NP and poly-5A6NP layers and formation of their reduced forms on the GC electrode surface were verified by cyclic voltammetry, electrochemical impedance spectroscopy, contact angle measurements, ellipsometry and X-ray photoelectron spectroscopy. The applicability of poly-5NP-and poly-5A6NP-functionalized carbon surfaces for the determination of Cu(II) ions was demonstrated by formation of complexes between GC-grafted poly-5NP and poly-5A6NP layers and Cu(II) ions.Sensors and Actuators B Chemical 01/2012; 166– 167(166– 167):117– 127. · 3.90 Impact Factor