Article

A novel amperometric sensor for the detection of difenidol hydrochloride based on the modification of Ru(bpy)(3)(2+) on a glassy carbon electrode.

College of Chemistry & Chemical Engineering, Hunan University, Changsha, China.
Talanta (impact factor: 3.79). 11/2007; 73(4):651-5. DOI:10.1016/j.talanta.2007.04.034 pp.651-5
Source: PubMed

ABSTRACT An amperometric sensor for the detection of difenidol, a tertiary amine-containing analyte, was proposed. Ruthenium(II) tris(bipyridine)/multi-walled carbon nanotubes/Nafion composite film was suggested to modify the glassy carbon electrode. The modified electrode was shown to be an excellent amperometric sensor for the detection of difenidol hydrochloride. The linear range is from 1.0x10(-6) to 3.3x10(-5)M with a correlation coefficient of 0.998. The limit of detection was 5x10(-7)M, which was obtained through experimental determination based on a signal-to-noise ratio of three. The sensor was employed to the determination of the active ingredients in the tablets containing difenidol hydrochloride.

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Keywords

amperometric sensor
 
correlation coefficient
 
difenidol hydrochloride
 
excellent amperometric sensor
 
experimental determination
 
glassy carbon electrode
 
linear range
 
modified electrode
 
Ruthenium(II)
 
signal-to-noise ratio
 
tertiary amine-containing analyte
 

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