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Small RNA-Directed Silencing: The Fly Finds Its Inner Fission Yeast?

RNA Therapeutics Institute, Howard Hughes Medical Institute, and Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Current biology: CB (Impact Factor: 9.92). 04/2013; 23(8):R318-20. DOI: 10.1016/j.cub.2013.03.033
Source: PubMed

ABSTRACT Several recent studies demonstrate that piRNAs guide Piwi protein to repress transposon transcription in fly ovaries, much as fission yeast use siRNAs to silence repeat sequences. Still mysterious though is how Piwi targets euchromatic transposons for silencing, but not the specialized heterochromatic loci that produce piRNA precursors.

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