Basal cell carcinoma does metastasize

Department of Surgery, University of California San Francisco, VA Medical Center San Francisco, California, USA.
Dermatology online journal 02/2008; 14(8):5.
Source: PubMed


Basal cell carcinoma (BCC) rarely metastasizes. However, this unfortunate outcome can occur, usually in neglected tumors. We report a 52-year-old man with a BCC on the left chest that enlarged and then ulcerated over a 6-year period. Metastasis of the tumor to lymph nodes in the left axilla resulted, but the patient remains free of disease 24 months after wide excision, lymph node dissection, and local radiation therapy to the axilla.

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    • "While bone invasion by BCC is well reported in the head and neck region,8-12 direct long bone invasion is not. To our knowledge, only 8 cases of BCC with direct long bone invasion have been reported in the literature, and only one of them was in the upper extremity.2,5,8,13-17 We report a case of basal cell carcinoma with a rare presentation of aggressive invasion of a long bone. "
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    ABSTRACT: Introduction: Basal cell carcinoma is the most prevalent form of cancer worldwide, usually arising in the head and neck region, which is cured by surgical excision and rarely invades or metastasizes. Many reports exist of bony invasion in the head and neck but very rarely into long bones. Methods: We report an unusual case of basal cell carcinoma that despite surgical excision, directly invaded the left humerus. This article also includes a literature review with possible explanations for the occasionally aggressive behavior of basal cell carcinoma. Results: This 68-year-old patient underwent wide resection of the affected left upper arm skin, tissue, and diaphyseal segment with clear margins. The defect was reconstructed with a vascularized free fibula bone graft, pedicled latissimus muscle flap, and split-thickness skin graft. Conclusions: Long bone invasion by BCC is extremely rare and not well reported. There are more biologic explanations for overtly aggressive behavior that BCC may exhibit such as in this case.
    Eplasty 11/2013; 13:e59.
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    • "Most of these tumors arise in the head and neck area, particularly in the elderly, and usually grow slowly. The metastatic potential is very low and is mainly detected in association with aggressive or longstanding , large neglected tumors [1] [2] [3] [4]. The characteristics of BCCs suggest that they might well be the " ideal candidates " for neglected tumors. "
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    ABSTRACT: Although tumors on the surface of the skin are considered to be easily recognizable, neglected advanced skin neoplasms are encountered even in the 21st century. There can be numerous causes of the delay in the diagnosis: fear of the diagnosis and the treatment, becoming accustomed to a slowly growing tumor, old age, a low social milieu, and an inadequate hygienic culture are among the factors leading some people not to seek medical advice. The treatment of such advanced neoplasms is usually challenging. The therapy of neglected cases demands an individual multidisciplinary approach and teamwork. Basal cell carcinoma (BCC), the most common cutaneous tumor, usually develops in the elderly, grows slowly, and has an extremely low metastatic potential; these factors are suggesting that BCCs might well be the "ideal candidates" for neglected tumors. Five neglected advanced cases of BCC were diagnosed in our dermatological institute between 2000 and 2009. The clinical characteristics and treatment modalities of these neoplasms are discussed, together with the possible causes of the neglect.
    01/2011; 2011:392151. DOI:10.1155/2011/392151

  • Australasian Journal of Dermatology 11/2009; 50(4):297; author reply 297-8. DOI:10.1111/j.1440-0960.2009.00563.x · 1.11 Impact Factor
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